Differentiation between malignant and benign musculoskeletal tumors using diffusion kurtosis imaging.
Objective: The purpose of this study was to evaluate differences in parameters of diffusion kurtosis imaging (DKI) and minimum apparent diffusion coefficient (ADCmin) between benign and malignant musculoskeletal tumors.Materials and Methods: In this prospective study, 43 patients were scanned using...
| Publicado en: | Skeletal Radiology Vol. 48; no. 2; pp. 285 - 293 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133695353&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133695353 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Feb2019 vid: 48 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133695353 133695353 NLM29740660 10.1007/s00256-018-2946-0 NLM29740660 133695353 ppf: 285 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differentiation between malignant and benign musculoskeletal tumors using diffusion kurtosis imaging. aug: au: Ogawa, Masaki Kan, Hirohito Arai, Nobuyuki Murai, Taro Manabe, Yoshihiko Sawada, Yusuke Shibamoto, Yuta affil: Department of Radiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan sug: subj: Soft Tissue Neoplasms Magnetic Resonance Imaging Methods Bone Neoplasms Adult Male Diagnosis, Differential Aged Image Enhancement Middle Age Female Image Interpretation, Computer Assisted Prospective Studies Scales Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Objective: The purpose of this study was to evaluate differences in parameters of diffusion kurtosis imaging (DKI) and minimum apparent diffusion coefficient (ADCmin) between benign and malignant musculoskeletal tumors.Materials and Methods: In this prospective study, 43 patients were scanned using a DKI protocol on a 3-T MR scanner. Eligibility criteria were: non-fatty, non-cystic soft tissue or osteolytic tumors; > 2 cm; location in the retroperitoneum, pelvis, leg, or neck; and no prior treatment. They were clinically or histologically diagnosed as benign (n = 27) or malignant (n = 16). In the DKI protocol, diffusion-weighted imaging was performed using four b values (0-2000 s/mm2) and 21 diffusion directions. Mean kurtosis (MK) values were calculated on the MR console. A recently developed software application enabling reliable calculation was used for DKI analysis.Results: MK showed a strong correction with ADCmin (Spearman's rs = 0.95). Both MK and ADCmin values differed between benign and malignant tumors (p < 0.01). For benign and malignant tumors, the mean MK values (± SD) were 0.49 ± 0.17 and 1.14 ± 0.30, respectively, and ADCmin values were 1.54 ± 0.47 and 0.49 ± 0.17 × 10-3 mm2/s, respectively. At cutoffs of MK = 0.81 and ADCmin = 0.77 × 10-3 mm2/s, the specificity and sensitivity for diagnosis of malignant tumors were 96.3 and 93.8% for MK and 96.3 and 93.8% for ADCmin, respectively. The areas under the curve were 0.97 and 0.99 for MK and ADCmin, respectively (p = 0.31).Conclusions: MK and ADCmin showed high diagnostic accuracy and strong correlation, reflecting the accuracy of MK. However, no clear added value of DKI could be demonstrated in differentiating musculoskeletal tumors. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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