Short-term prediction of glucose in type 1 diabetes using kernel adaptive filters.

This study aims at presenting a nonlinear, recursive, multivariate prediction model of the subcutaneous glucose concentration in type 1 diabetes. Nonlinear regression is performed in a reproducing kernel Hilbert space, by either the fixed budget quantized kernel least mean square (QKLMS-FB) or the a...

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Publicado en:Medical & Biological Engineering & Computing Vol. 57; no. 1; pp. 27 - 47
Autores principales: Georga, Eleni I., Príncipe, José C., Fotiadis, Dimitrios I.
Formato: equations & formulas research tables/charts Journal Article
Publicado: Springer Nature Jan2019
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Jan2019
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      pub: Springer Nature
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        atl: Short-term prediction of glucose in type 1 diabetes using kernel adaptive filters.
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          Georga, Eleni I.
          Príncipe, José C.
          Fotiadis, Dimitrios I.
        affil: Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, Ioannina, Greece
      sug:
        subj:
          Diabetes Mellitus, Type 1 Blood
          Blood Glucose Analysis
          Algorithms
          Female
          ROC Curve
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          Arthritis Impact Measurement Scales
          Short Portable Mental Status Questionnaire
          Adult: 19-44 years
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      ab: This study aims at presenting a nonlinear, recursive, multivariate prediction model of the subcutaneous glucose concentration in type 1 diabetes. Nonlinear regression is performed in a reproducing kernel Hilbert space, by either the fixed budget quantized kernel least mean square (QKLMS-FB) or the approximate linear dependency kernel recursive least-squares (KRLS-ALD) algorithm, such that a sparse model structure is accomplished. A multivariate feature set (i.e., subcutaneous glucose, food carbohydrates, insulin regime and physical activity) is used and its influence on short-term glucose prediction is investigated. The method is evaluated using data from 15 patients with type 1 diabetes in free-living conditions. In the case when all the input variables are considered: (i) the average root mean squared error (RMSE) of QKLMS-FB increases from 13.1 mg dL-1 (mean absolute percentage error (MAPE) 6.6%) for a 15-min prediction horizon (PH) to 37.7 mg dL-1 (MAPE 20.8%) for a 60-min PH and (ii) the RMSE of KRLS-ALD, being predictably lower, increases from 10.5 mg dL-1 (MAPE 5.2%) for a 15-min PH to 31.8 mg dL-1 (MAPE 18.0%) for a 60-min PH. Multivariate data improve systematically both the regularity and the time lag of the predictions, reducing the errors in critical glucose value regions for a PH ≥ 30 min. Graphical abstract ᅟ.
      pubtype: Academic Journal
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        equations & formulas
        research
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    language: English
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