Comparison of titanium dioxide scaffold with commercial bone graft materials through micro-finite element modelling in flow perfusion.
TiO2 scaffolds have previously shown to have promising osteoconductive properties in previous in vivo experiments. Appropriate mechanical stimuli can further promote this osteoconductive behaviour. However, the complex mechanical environment and the mechanical stimuli enhancing bone regeneration for...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 57; no. 1; pp. 311 - 325 |
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| Autores principales: | , , |
| Formato: | equations & formulas pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133800698&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133800698 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Jan2019 vid: 57 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 133800698 133800698 NLM30117067 133800698 10.1007/s11517-018-1884-2 NLM30117067 133800698 ppf: 311 ppct: 14 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of titanium dioxide scaffold with commercial bone graft materials through micro-finite element modelling in flow perfusion. aug: au: Zhang, Xianbin Tiainen, Hanna Haugen, Håvard J. affil: Department of Biomaterials, Institute of Clinical Dentistry, University of Oslo, PO Box 1109, Blindern, 0317, Oslo, Norway sug: subj: Titanium Pharmacodynamics Culture Media Perfusion Biocompatible Materials Pharmacodynamics Bone Transplantation Rheology Finite Element Analysis Stress, Mechanical Computer Simulation Physiochemical Phenomena Viscosity Permeability Physics Elasticity Reproducibility of Results Pressure Validation Studies Comparative Studies Evaluation Research Multicenter Studies Funding Source Human ab: TiO2 scaffolds have previously shown to have promising osteoconductive properties in previous in vivo experiments. Appropriate mechanical stimuli can further promote this osteoconductive behaviour. However, the complex mechanical environment and the mechanical stimuli enhancing bone regeneration for porous bioceramics have not yet been fully elucidated. This paper aims to compare and evaluate mechanical environment of TiO2 scaffold with three commercial CaP biomaterials, i.e. Bio-Oss, Cerabone and Maxresorb under simulated perfusion culture conditions. The solid phase and fluid phase were modelled as linear elastic material and Newtonian fluid, respectively. The mechanical stimulus was analysed within these porous scaffolds quantitatively. The results showed that the TiO2 had nearly heterogeneous stress distributions, however lower effective Young's modulus than Cerabone and Maxresorb. The permeability and wall shear stress (WSS) for the TiO2 scaffold was significantly higher than other commercial bone substitute materials. Maxresorb and Bio-Oss showed lowest permeability and local areas of very high WSS. The detailed description of the mechanical performance of these scaffolds could help researchers to predict cell behaviour and to select the most appropriate scaffold for different in vitro and in vivo performances. Graphical abstract Schematic representation of the establishment procedure. Take the establishment process of Cerabone as an example. Left shows a slice of micro-CT image from Cerabone, and 1.5 mm × 1.5 mm region of interest was shown in the red box. A 1.5-mm3 cube was cut out by Boolean operation in Mimics (Materialise, Belgium), and the cubic model was remeshed in 3-Matic 6.0 (Materialise, Belgium). The cubic model is shown in blue, and the empty space in red. pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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