Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot Randomized Trial.
Nutritional approaches to improve dyslipidemias have been recently developed, but evidences on different medical foods are often incomplete. The main aim of our study was to evaluate the effects on endothelial function, lipid profile, and glucose metabolism of two different combinations of nutraceut...
| Publicado en: | BioMed Research International pp. 1 - 8 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Wiley-Blackwell
1/6/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=133947398&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 133947398 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 23146133 FT2T jtl: BioMed Research International issn: 23146133 maglogo: N pubinfo: dt: 1/6/2019 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 133947398 133947398 133947398 10.1155/2019/1970878 133947398 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effects of a New Combination of Medical Food on Endothelial Function and Lipid Profile in Dyslipidemic Subjects: A Pilot Randomized Trial. aug: au: Landi, Francesco Martone, Anna Maria Salini, Sara Zazzara, Beatrice Calvani, Riccardo Marzetti, Emanuele Nesci, Antonio Di Giorgio, Angela Giupponi, Bianca Santoro, Luca Santoliquido, Angelo affil: Department of Geriatrics, Neurosciences and Orthopedics, Fondazione Policlinico Gemelli IRCCS, Roma, Italy sug: subj: Hyperlipidemia Drug Therapy Functional Food Therapeutic Use Drug Combinations Endothelium Drug Effects Lipids Drug Effects Blood Glucose Drug Effects Human Pilot Studies Randomized Controlled Trials Citrus Folic Acid Administration and Dosage Coenzyme Q Administration and Dosage Lovastatin Administration and Dosage Plant Extracts Administration and Dosage Alkaloids Administration and Dosage Fatty Acids, omega-3 Administration and Dosage Xanthines Administration and Dosage Folic Acid Pharmacodynamics Plant Extracts Pharmacodynamics Fatty Acids, omega-3 Pharmacodynamics Alkaloids Pharmacodynamics Coenzyme Q Pharmacodynamics Lovastatin Pharmacodynamics Xanthines Pharmacodynamics ab: Nutritional approaches to improve dyslipidemias have been recently developed, but evidences on different medical foods are often incomplete. The main aim of our study was to evaluate the effects on endothelial function, lipid profile, and glucose metabolism of two different combinations of nutraceuticals, first one containing Bergavit (200 mg Citrus bergamia), Omega-3 (400 mg), Crominex 3+ (10 mcg trivalent chromium), and red yeast rice (100 mg; 5 mg monacolin K) and second one containing red yeast rice (200 mg; 3 mg monacolin K), Berberine (500 mg), Astaxanthin (0.5 mg), folic acid (200 mcg), Coenzyme Q10 (2 mg), and Policosanol (10 mg). Fifty subjects affected by dyslipidemia not requiring statin treatment were enrolled in this randomized, blind, controlled trial and submitted to blood sampling for lipid and glucose profiles and instrumental evaluation of endothelial function before and after 6 weeks of treatment with nutraceuticals. Both nutraceutical combinations improved the lipid profile; the nutraceutical containing 5 mg of monacolin K, 200 mg of the extract Citrus bergamia, 400 mg of Omega-3, and 10 mcg of trivalent chromium entailed a significant improvement of endothelial function with enhanced cholesterol lowering effect. In conclusion, this study confirms the positive effect of functional food on lipid profile and endothelial function in absence of major undesirable effects. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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