Sensitivity of Cerebrospinal Fluid Cytology for the Diagnosis of Cryptococcal Infections: A 21-Year Single-Institution Retrospective Review.
Objectives: Cryptococcal meningoencephalitis is the most common fungal infection of the central nervous system diagnosed by cerebrospinal fluid cytology (CSF) studies. Existing literature suggests that routine CSF cytomorphologic evaluations are exquisitely specific; however, less is known about the...
| Publicado en: | American Journal of Clinical Pathology Vol. 151; no. 2; pp. 198 - 205 |
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| Autores principales: | , , , , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134019016&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134019016 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00029173 2RW jtl: American Journal of Clinical Pathology issn: 00029173 maglogo: N pubinfo: dt: Feb2019 vid: 151 iid: 2 pid: 10398 pub: Oxford University Press / USA artinfo: ui: 134019016 134019016 NLM30321269 134019016 10.1093/ajcp/aqy133 NLM30321269 134019016 ppf: 198 ppct: 7 formats: tig: atl: Sensitivity of Cerebrospinal Fluid Cytology for the Diagnosis of Cryptococcal Infections: A 21-Year Single-Institution Retrospective Review. aug: au: McHugh, Kelsey E Gersey, Melanie Procop, Gary W Booth, Christine N Sturgis, Charles D Rhoads, Daniel D Zhang, Yaxia affil: Department of Laboratory Medicine, Cleveland Clinic, Cleveland, OH sug: subj: Cryptococcus Immunology Cryptococcosis Diagnosis Antigens, Fungal Cerebrospinal Fluid Retrospective Design Cryptococcus Cryptococcosis Microbiology Cryptococcosis Cerebrospinal Fluid Sensitivity and Specificity Predictive Value of Tests Cytodiagnosis Human ab: Objectives: Cryptococcal meningoencephalitis is the most common fungal infection of the central nervous system diagnosed by cerebrospinal fluid cytology (CSF) studies. Existing literature suggests that routine CSF cytomorphologic evaluations are exquisitely specific; however, less is known about their sensitivity.Methods: An electronic record review of the cytopathology and microbiology files was conducted for the 21-year interval from January 1, 1995, through December 31, 2015.Results: In 21 years, 12,584 CSF samples were processed in the laboratory. Of these, 24 (0.2%) were reported positive for cryptococcal organisms by light microscopy, and 129 CSF fungal cultures were positive for Cryptococcus species. All cotested specimens with positive cytology results were positive on culture (15 specimens, 100% specificity). Twenty-four samples with positive culture results were negative by CSF cytology (sensitivity 39%).Conclusions: When culture is used as a gold standard, CSF cytology is 100% specific and 39% sensitive, with a positive predictive value of 100% and a negative predictive value of 99.8%. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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