Desaturations During 6-Minute Walk Test and Predicting Nocturnal Desaturations in Adult Subjects With Cystic Fibrosis.
BACKGROUND: Nocturnal desaturation in cystic fibrosis (CF) may have prognostic implications because a significant and maintained nocturnal desaturation can contribute to the development and progression of pulmonary hypertension with cor pulmonale. Its relation with the desaturation in exercise has n...
| Publicado en: | Respiratory Care Vol. 64; no. 1; pp. 48 - 55 |
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| Autores principales: | , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134047071&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134047071 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Jan2019 vid: 64 iid: 1 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 134047071 134047071 134047071 10.4187/respcare.06171 134047071 ppf: 48 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Desaturations During 6-Minute Walk Test and Predicting Nocturnal Desaturations in Adult Subjects With Cystic Fibrosis. aug: au: Gómez Punter, Rosa Mar Girón Moreno, Rosa M. Vázquez Espinosa, Emma Soriano, Joan B. Zamora, Enrique Valenzuela, Claudia Alonso, Tamara Castillo, Elena García Ancochea, Julio affil: Servicio de Neumología. Instituto de Investigación Sanitaria Princesa (IISP), Hospital Universitario La Princesa, Universidad Autónoma de Madrid, Madrid, Spain sug: subj: Cystic Fibrosis In Adulthood Oxygen Saturation Walking Sleep Disorders Complications Human Clinical Assessment Tools Spirometry Utilization Male Female Descriptive Statistics Forced Expiratory Volume Carbon Monoxide Metabolism Blood Gas Analysis Pulse Oximetry Adolescence Adult Middle Age Aged Aged, 80 and Over Spain Quality of Life Pearson's Correlation Coefficient T-Tests Analysis of Variance Spearman's Rank Correlation Coefficient Friedman Test Mann-Whitney U Test Questionnaires Qualitative Studies Data Analysis Software Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: BACKGROUND: Nocturnal desaturation in cystic fibrosis (CF) may have prognostic implications because a significant and maintained nocturnal desaturation can contribute to the development and progression of pulmonary hypertension with cor pulmonale. Its relation with the desaturation in exercise has not been sufficiently studied. We aimed to determine whether desaturation during 6MWT can be an indicator of nocturnal desaturation in adult subjects with CF. METHODS: 57 subjects were included: 50.9% male, 27.5 ± 7.7 y old, mean FEV1 = 2.37 ± 0.74 L, and %FEV1 67 ± 18.1%. Desaturation during 6MWT was defined as oxygen saturation (SpO2) < 90% or a decline of > 4 points in ... from baseline, and nocturnal desaturation as a desaturation index > 4 or > 5% of sleep time with ... < 90%. RESULTS: Desaturation observed during 6MWT in adult subjects with CF did not correlate with nocturnal desaturation (P = .27). Subjects with %FEV1 ≤ 55% and diffusion capacity of carbon monoxide (DLCO) ≤ 50 mmol/min/mm Hg were at higher risk of 6MWT desaturation. Nocturnal desaturation was more frequent in males, with PaO2 ≤ 71 mm Hg in blood gas analysis. CONCLUSIONS: Desaturation observed in 6MWT cannot predict desaturation at night in adults with CF. Other parameters were identified as predictors of desaturation. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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