The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production.
Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive ea...
| Publicado en: | Genetics Vol. 211; no. 1; pp. 201 - 218 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Oxford University Press / USA
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134084358&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134084358 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00166731 GNT jtl: Genetics issn: 00166731 maglogo: N pubinfo: dt: Jan2019 vid: 211 iid: 1 pid: 622 pub: Oxford University Press / USA artinfo: ui: 134084358 10.1534/genetics.118.301704 134084358 ppf: 201 ppct: 17 formats: tig: atl: The Role of Maternal HP1a in Early Drosophila Embryogenesis via Regulation of Maternal Transcript Production. aug: au: Ah Rume Park Na Liu Nils Neuenkirchen Qiaozhi Guo Haifan Lin affil: Yale Stem Cell Center, Yale University School of Medicine, New Haven, Connecticut 06520 sug: subj: Insects Physiology Chromosomes Cell Physiology Fetal Development Biochemical Phenomena Genetics Animal Studies Cell Differentiation Cell Division RNA, Messenger Germ Cells ab: Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early Drosophila embryogenesis. Maternal HP1a upregulates genes involved in translation, mRNA splicing, and cell division, but downregulates genes involved in neurogenesis, organogenesis, and germline development, which all occur later in development. Our study reveals the earliest contribution of HP1a during oogenesis in regulating the production of maternal transcripts that drive early Drosophila embryogenesis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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