Estimating with confidence the risk of rare adverse events, including those with observed rates of zero.
Omission of a confidence interval (CI) associated with the risk of a serious complication can lead to inaccurate interpretation of risk data. The calculation of a CI for a risk or a single proportion typically uses the familiar Gaussian (normal) approximation. However, when the risk is small, "exact...
| Publicado en: | Regional Anesthesia & Pain Medicine Vol. 27; no. 2; pp. 207 - 211 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
BMJ Publishing Group
2002 Mar-Apr
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134086594&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134086594 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10987339 DPG jtl: Regional Anesthesia & Pain Medicine issn: 10987339 maglogo: N pubinfo: dt: 2002 Mar-Apr vid: 27 iid: 2 pid: 8280 pub: BMJ Publishing Group artinfo: ui: 134086594 134086594 NLM11915070 134086594 NLM11915070 134086594 ppf: 207 ppct: 4 formats: tig: atl: Estimating with confidence the risk of rare adverse events, including those with observed rates of zero. aug: au: Ho, Anthony M-H Dion, Peter W Karmakar, Manoj K Lee, Anna affil: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China sug: subj: Confidence Intervals Anesthesia Adverse Effects Relative Risk Human Anesthesia, Conduction Pain Clinics Validation Studies Comparative Studies Evaluation Research Multicenter Studies Checklists ab: Omission of a confidence interval (CI) associated with the risk of a serious complication can lead to inaccurate interpretation of risk data. The calculation of a CI for a risk or a single proportion typically uses the familiar Gaussian (normal) approximation. However, when the risk is small, "exact" methods or other special techniques should be used to avoid overshooting (risks that include values outside of [0,1]) and zero width interval degeneration. Computer programs and simple equations are available to construct CIs reasonably accurately. In the special case in which the complication has not occurred, the risk estimated with 95% confidence is no worse than 3/n, where n is the number of trials. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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