Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study.
Background: High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being diagnosed with a large-sized or interval breast cancer.Methods: Within a prospec...
| Publicado en: | Breast Cancer Research Vol. 21; no. 1 |
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| Autores principales: | , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
BioMed Central
1/22/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134228346&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134228346 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 1/22/2019 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 134228346 134228346 NLM30670066 134228346 10.1186/s13058-019-1099-y NLM30670066 134228346 ppct: 1 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Localized mammographic density is associated with interval cancer and large breast cancer: a nested case-control study. aug: au: Strand, Fredrik Azavedo, Edward Hellgren, Roxanna Humphreys, Keith Eriksson, Mikael Shepherd, John Hall, Per Czene, Kamila affil: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12A, 171 77, Stockholm, Sweden sug: subj: Health Screening Methods Diagnosis, Delayed Breast Neoplasms Early Detection of Cancer Methods Time Factors Case Control Studies Breast Pathology Human Middle Age Female Prospective Studies Image Processing, Computer Assisted Methods Breast Neoplasms Pathology Breast Mammography Methods False Negative Results Body Weights and Measures Retrospective Design Validation Studies Comparative Studies Evaluation Research Multicenter Studies Barthel Index Psychological Tests Funding Source Middle Aged: 45-64 years Female ab: Background: High mammographic density is associated with breast cancer and with delayed detection. We have examined whether localized density, at the site of the subsequent cancer, is independently associated with being diagnosed with a large-sized or interval breast cancer.Methods: Within a prospective cohort of 63,130 women, we examined 891 women who were diagnosed with incident breast cancer. For 386 women, retrospective localized density assessment was possible. The main outcomes were interval cancer vs. screen-detected cancer and large (> 2 cm) vs. small cancer. In negative screening mammograms, overall and localized density were classified reflecting the BI-RADS standard. Density concordance probabilities were estimated through multinomial regression. The associations between localized density and the two outcomes were modeled through logistic regression, adjusted for overall density, age, body mass index, and other characteristics.Results: The probabilities of concordant localized density were 0.35, 0.60, 0.38, and 0.32 for overall categories "A," "B," "C," and "D." Overall density was associated with large cancer, comparing density category D to A with OR 4.6 (95%CI 1.8-11.6) and with interval cancer OR 31.5 (95%CI 10.9-92) among all women. Localized density was associated with large cancer at diagnosis with OR 11.8 (95%CI 2.7-51.8) among all women and associated with first-year interval cancer with OR 6.4 (0.7 to 58.7) with a significant linear trend p = 0.027.Conclusions: Overall density often misrepresents localized density at the site where cancer subsequently arises. High localized density is associated with interval cancer and with large cancer. Our findings support the continued effort to develop and examine computer-based measures of localized density for use in personalized breast cancer screening. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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