Dopaminergic influences on risk preferences of Parkinson's disease patients.
Clinicians are increasingly recognizing impulse control disorders (ICDs) as a complication of dopaminergic treatment in Parkinson's disease (PD). Considering the pivotal role of dopamine in reward information processing, ICDs may originate from dysregulation of reward-oriented behavior, and the beha...
| Publicado en: | Cognitive, Affective & Behavioral Neuroscience Vol. 19; no. 1; pp. 88 - 98 |
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| Autores principales: | , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134264936&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134264936 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15307026 NA4 jtl: Cognitive, Affective & Behavioral Neuroscience issn: 15307026 maglogo: N pubinfo: dt: Feb2019 vid: 19 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134264936 10.3758/s13415-018-00646-3 134264936 ppf: 88 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Dopaminergic influences on risk preferences of Parkinson's disease patients. aug: au: Kobayashi, Shunsuke Asano, Kohei Matsuda, Nozomu Ugawa, Yoshikazu affil: Department of Neurology, Fukushima Medical University, 1 Hikarigaoka, Fukushima-shi, 960-1295, Fukushima-ken, Japan sug: ab: Clinicians are increasingly recognizing impulse control disorders (ICDs) as a complication of dopaminergic treatment in Parkinson's disease (PD). Considering the pivotal role of dopamine in reward information processing, ICDs may originate from dysregulation of reward-oriented behavior, and the behavioral changes may be reflected in shifts of psychological risk preference during decision-making. We used a behavioral economics paradigm to evaluate quantitatively the risk preferences of PD patients in levodopa on and off states. We also examined age-matched healthy controls. We found that levodopa increased the subjective value and prolonged the decision time in PD patients. These effects are apparently not explained by kinematic improvements but are attributed to psychological shifts of risk preferences and increased attention during risky decision-making. The risk preferences of healthy controls were similar to those of PD on levodopa treatment. The risk preferences of PD patients were not correlated with the scores of routine cognitive batteries, suggesting that dopamine-sensitive risk preferences are independent of cognitive capacities as measured by conventional batteries, including general intelligence, memory, and frontal functioning. By contrast, apathy and ICD partially predicted the risk attitude in PD patients, suggesting a common background of limbic origin behind these properties. The present results demonstrated that dopamine deficiency in off-state PD leads to risk-avoiding behavior and levodopa treatment increases the risk preferences. Behavioral economics framework is useful to evaluate short-term psychological changes in response to levodopa in PD patients. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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