Resolving Interobserver Discrepancies in Lung Cancer Diagnoses by Spectral Histopathology.
* This paper reports the results of a collaborative lung cancer study between City of Hope Cancer Center (Duarte, California) and CIRECA, LLC (Cambridge, Massachusetts), comprising 328 samples from 249 patients, that used an optical technique known as spectral histopathology (SHP) for tissue classif...
| Publicado en: | Archives of Pathology & Laboratory Medicine Vol. 143; no. 2; pp. 157 - 174 |
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| Autores principales: | , , , , , |
| Formato: | pictorial review tables/charts Journal Article |
| Publicado: |
College of American Pathologists
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134272548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134272548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00039985 1FS jtl: Archives of Pathology & Laboratory Medicine issn: 00039985 maglogo: N pubinfo: dt: Feb2019 vid: 143 iid: 2 pid: 2550 pub: College of American Pathologists place: Northfield, Illinois artinfo: ui: 134272548 134272548 134272548 10.5858/arpa.2017-0476-SA 134272548 ppf: 157 ppct: 17 formats: fmt: @attributes: type: P tig: atl: Resolving Interobserver Discrepancies in Lung Cancer Diagnoses by Spectral Histopathology. aug: au: Akalin, Ali Ergin, Ayşegül Remiszewski, Stanley Xinying Mu Raz, Dan Diem, Max affil: Department of Pathology, University of Massachusetts Medical School, Worcester sug: subj: Lung Neoplasms Diagnosis Lung Neoplasms Pathology Histological Techniques Methods Interrater Reliability Sensitivity and Specificity Immunohistochemistry Adenocarcinoma Classification Carcinoma, Squamous Cell Classification Early Detection of Cancer Mass Spectrometry Methods Biochemical Phenomena ab: * This paper reports the results of a collaborative lung cancer study between City of Hope Cancer Center (Duarte, California) and CIRECA, LLC (Cambridge, Massachusetts), comprising 328 samples from 249 patients, that used an optical technique known as spectral histopathology (SHP) for tissue classification. Because SHP is based on a physical measurement, it renders diagnoses on a more objective and reproducible basis than methods based on assessing cell morphology and tissue architecture. This report demonstrates that SHP provides distinction of adenocarcinomas from squamous cell carcinomas of the lung with an accuracy comparable to that of immunohistochemistry and highly reliable classification of adenosquamous carcinoma. Furthermore, this report shows that SHP can be used to resolve interobserver differences in lung pathology. Spectral histopathology is based on the detection of changes in biochemical composition, rather than morphologic features, and is therefore more akin to methods such as matrix-assisted laser desorption ionization time-of-flight mass spectrometry imaging. Both matrixassisted laser desorption ionization time-of-flight mass spectrometry and SHP imaging modalities demonstrate that changes in tissue morphologic features observed in classical pathology are accompanied by, and may be correlated to, changes in the biochemical composition at the cellular level. Thus, these imaging methods provide novel insight into biochemical changes due to disease. pubtype: Academic Journal doctype: pictorial review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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