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Managing Ulcers Associated with Pyoderma Gangrenosum with a Urinary Bladder Matrix and Negative-Pressure Wound Therapy.

Pyoderma gangrenosum (PG) is a rare disease that presents as painful ulcerations with inflammation and undermining at the borders. The ulcers can occur anywhere on the body but are most commonly seen on the lower extremities. The etiology of PG is unknown, and there are no definitive diagnostic crit...

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Published in:Advances in Skin & Wound Care Vol. 32; no. 2; pp. 70 - 77
Main Authors: Sanger Dillingham, Claire, Jorizzo, Joseph
Format: case study pictorial tables/charts Journal Article
Published: Lippincott Williams & Wilkins Feb2019
Online Access:View this record in EBSCOhost
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        15277941
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      jtl: Advances in Skin & Wound Care
      issn: 15277941
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      dt: Feb2019
      vid: 32
      iid: 2
      pid: 5086
      pub: Lippincott Williams & Wilkins
      place: Baltimore, Maryland
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        10.1097/01.ASW.0000546120.32681.bc
        134272917
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        atl: Managing Ulcers Associated with Pyoderma Gangrenosum with a Urinary Bladder Matrix and Negative-Pressure Wound Therapy.
      aug:
        au:
          Sanger Dillingham, Claire
          Jorizzo, Joseph
        affil: Associate Professor, Plastic and Reconstructive Surgery Department, Wake Forest Baptist Medical University in Winston-Salem, North Carolina
      sug:
        subj:
          Pyoderma Gangrenosum Therapy
          Bladder
          Wound Healing
          Negative Pressure Wound Therapy
          Surgery, Reconstructive
          Aged
          Male
          Blood Glucose
          Pain Management
          Antibiotics
          Tomography, X-Ray Computed
          Cellulitis
          Debridement
          Leukocytes
          Prednisone
          Polymyxin B
          Bacitracin
          Skin Transplantation
          Aged: 65+ years
          Male
      ab: Pyoderma gangrenosum (PG) is a rare disease that presents as painful ulcerations with inflammation and undermining at the borders. The ulcers can occur anywhere on the body but are most commonly seen on the lower extremities. The etiology of PG is unknown, and there are no definitive diagnostic criteria; PG is a diagnosis of exclusion, which can present serious delays in treatment. Patients should be treated with an interdisciplinary approach with aggressive immunosuppression, treatment of any comorbidities, maximization of nutrition status, reconstructive surgery for treatment of the wound, and physical therapy for deconditioning. This article presents a case study of one patient treated with a porcine urinary bladder matrix and negative-pressure wound therapy; this treatment combination provided pain relief, coverage of the wound, an acceptable aesthetic outcome, and long-term stability.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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