Hairy cell leukemia presenting with Ecthyma Gangrenosum- a case report.

Background: Ecthyma gangrenosum is a cutaneous infectious usually associated with P. aeruginosa. It usually develops In patients with an underlying immunodeficiency.Case Presentation: A 50-year old mentally disabled white male with a history of epilepsy presented with fever and a painless red macule...

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Publicado en:BMC Infectious Diseases Vol. 19; no. 1; pp. 1 - 5
Autores principales: Sluga, R., Tersmette, M., Sohne, M.
Formato: case study pictorial tables/charts Journal Article
Publicado: BioMed Central 1/25/2019
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Hairy cell leukemia presenting with Ecthyma Gangrenosum- a case report.
      aug:
        au:
          Sluga, R.
          Tersmette, M.
          Sohne, M.
        affil: Department of Internal Medicine, St Antonius Hospital, Nieuwegein/ Utrecht, Koekoekslaan 1, 3435, Nieuwegein, CM, The Netherlands
      sug:
        subj:
          Pyoderma Diagnosis
          Leukemia Diagnosis
          Pseudomonas Infections Diagnosis
          Pseudomonas
          Pyoderma Microbiology
          Antibiotics Therapeutic Use
          Male
          Pseudomonas Infections Drug Therapy
          Fever Drug Therapy
          Middle Age
          Middle Aged: 45-64 years
          Male
      ab: Background: Ecthyma gangrenosum is a cutaneous infectious usually associated with P. aeruginosa. It usually develops In patients with an underlying immunodeficiency.Case Presentation: A 50-year old mentally disabled white male with a history of epilepsy presented with fever and a painless red macule on his right arm which rapidly progressed to a painful ulcer. Blood and lesion cultures revealed P.aeruginosa, confirming our clinical diagnosis of ecthyma gangrenosum. Subsequently an underlying immune deficit was found, namely patient was diagnosed with hairy-cell leukemia. Despite adequate antibiotics no infection control could be achieved. After treating the underlying immune deficit as well, the infection and hairy-cell leukemia resolved completely.Conclusion: Ecthyma gangrenosum is an important cutaneous infection to recognize, because it is it is typically associated with P.aeruginosa bacteremia. Recognizing this skin leasion should prompt empiric antimicrobial therapy including an agent with antipseudomonal activity. Furthermore, just like in our case, the presence of ecthyma gangrenosum can signal the presence of an occult immune deficit, warranting further investigation.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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