Maternal reproductive hormones and angiogenic factors in pregnancy and subsequent breast cancer risk.
Purpose: Breast cancer risk associated with pregnancy characteristics may be mediated by maternal hormones or angiogenic factors.Methods: We conducted a prospective breast cancer case-control study among women in the Avon Longitudinal Study of Parents and Children (ALSPAC) and Norwegian Mother and C...
| Publicado en: | Cancer Causes & Control Vol. 30; no. 1; pp. 63 - 75 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134367624&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134367624 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09575243 ODX jtl: Cancer Causes & Control issn: 09575243 maglogo: N pubinfo: dt: Jan2019 vid: 30 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134367624 134367624 NLM30506491 134367624 10.1007/s10552-018-1100-6 NLM30506491 134367624 ppf: 63 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Maternal reproductive hormones and angiogenic factors in pregnancy and subsequent breast cancer risk. aug: au: Cornish, Rosie Staff, Anne Cathrine Boyd, Andy Lawlor, Debbie A. Tretli, Steinar Bradwin, Gary McElrath, Thomas F. Hyer, Marianne Hoover, Robert N. Troisi, Rebecca affil: Population Health Sciences, Bristol Medical School, University of Bristol, Canynge Hall, 39 Whatley Road, BS8 2PS, Bristol, UK sug: subj: Breast Neoplasms Pathology Angiogenic Proteins Metabolism Middle Age Prospective Studies Odds Ratio Female Logistic Regression Adult Case Control Studies Norway Pregnancy Human Middle Aged: 45-64 years Adult: 19-44 years Female ab: Purpose: Breast cancer risk associated with pregnancy characteristics may be mediated by maternal hormones or angiogenic factors.Methods: We conducted a prospective breast cancer case-control study among women in the Avon Longitudinal Study of Parents and Children (ALSPAC) and Norwegian Mother and Child Cohort Study (MoBa) related to maternal pregnancy prolactin (n = 254 cases and 374 controls), placental growth factor (PlGF, n = 252 and 371), soluble fms-like tyrosine kinase-1 (sFlt-1, n = 118 and 240) and steroid hormone concentrations (ALSPAC only, n = 173 and 171). Odds ratios (OR) and 95% confidence intervals (CI) for a 1 SD change in analytes were estimated using unconditional logistic regression with matching factors (cohort, mother's birth year, serum/plasma, blood collection timing) and gestational age.Results: Breast cancer ORs (95% CI) were 0.85 (0.51-1.43) for estradiol, 0.86 (0.67-1.09) for testosterone, 0.89 (0.71-1.13) for androstenedione, 0.97 (0.71-1.34) for hCG, 0.93 (0.75, 1.15) for prolactin, 1.00 (0.78-1.27) for PlGF and 1.91 (1.00-3.65 ALSPAC) and 0.94 (0.73-1.21 MoBa) for sFlt-1, and were similar adjusting for potential confounders. Results were similar by blood collection timing, parity, age at first birth or diagnosis, and time between pregnancy and diagnosis.Conclusion: These data do not provide strong evidence of associations between maternal hormones or angiogenic factors with subsequent maternal breast cancer risk. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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