Hepatocellular carcinoma: CT texture analysis as a predictor of survival after surgical resection.
Objectives: To determine whether image texture parameters analysed on pre-operative contrast-enhanced computed tomography (CT) can predict overall survival and recurrence-free survival in patients with hepatocellular carcinoma (HCC) treated by surgical resection.Methods: We retrospectively included...
| Publicado en: | European Radiology Vol. 29; no. 3; pp. 1231 - 1240 |
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| Autores principales: | , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134415303&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134415303 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2019 vid: 29 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134415303 134415303 NLM30159621 10.1007/s00330-018-5679-5 NLM30159621 134415303 ppf: 1231 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Hepatocellular carcinoma: CT texture analysis as a predictor of survival after surgical resection. aug: au: Brenet Defour, Lucie Mulé, Sébastien Tenenhaus, Arthur Piardi, Tullio Sommacale, Daniele Hoeffel, Christine Thiéfin, Gérard affil: Service d'Hépato-Gastroentérologie et de Cancérologie Digestive, Centre Hospitalier Universitaire de Reims, 51092, Reims, France sug: subj: Hepatectomy Multidetector Computed Tomography Methods Carcinoma, Hepatocellular Diagnosis Liver Neoplasms Diagnosis Adult France Carcinoma, Hepatocellular Surgery Retrospective Design Liver Neoplasms Mortality Liver Neoplasms Surgery Male Carcinoma, Hepatocellular Mortality Aged, 80 and Over Female Postoperative Period Aged Survival Trends Prognosis Middle Age Adult: 19-44 years Aged, 80 & over Aged: 65+ years Middle Aged: 45-64 years Male Female ab: Objectives: To determine whether image texture parameters analysed on pre-operative contrast-enhanced computed tomography (CT) can predict overall survival and recurrence-free survival in patients with hepatocellular carcinoma (HCC) treated by surgical resection.Methods: We retrospectively included all patients operated for HCC who had liver contrast-enhanced CT within 3 months prior to treatment in our centre between 2010 and 2015. The following texture parameters were evaluated on late-arterial and portal-venous phases: mean grey-level, standard deviation, kurtosis, skewness and entropy. Measurements were made before and after spatial filtration at different anatomical scales (SSF) ranging from 2 (fine texture) to 6 (coarse texture). Lasso penalised Cox regression analyses were performed to identify independent predictors of overall survival and recurrence-free survival.Results: Forty-seven patients were included. Median follow-up time was 345 days (interquartile range [IQR], 176-569). Nineteen patients had a recurrence at a median time of 190 days (IQR, 141-274) and 13 died at a median time of 274 days (IQR, 96-411). At arterial CT phase, kurtosis at SSF = 4 (hazard ratio [95% confidence interval] = 3.23 [1.35-7.71] p = 0.0084) was independent predictor of overall survival. At portal-venous phase, skewness without filtration (HR [CI 95%] = 353.44 [1.31-95102.23], p = 0.039), at SSF2 scale (HR [CI 95%] = 438.73 [2.44-78968.25], p = 0.022) and SSF3 (HR [CI 95%] = 14.43 [1.38-150.51], p = 0.026) were independently associated with overall survival. No textural feature was identified as predictor of recurrence-free survival.Conclusions: In patients with resectable HCC, portal venous phase-derived CT skewness is significantly associated with overall survival and may potentially become a useful tool to select the best candidates for resection.Key Points: • HCC heterogeneity as evaluated by texture analysis of contrast-enhanced CT images may predict overall survival in patients treated by surgical resection. • Among texture parameters, skewness assessed at different anatomical scales at portal-venous phase CT is an independent predictor of overall survival after resection. • In patients with HCC, CT texture analysis may have the potential to become a useful tool to select the best candidates for resection. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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