Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population.
Objectives: Diverticular disease represents an increasing pathology and healthcare burden worldwide. Our aim was to study the prevalence, extent and distribution of asymptomatic diverticular disease assessed by magnetic resonance imaging (MRI) in a sample of a Western population.Methods: Subjects fr...
| Publicado en: | European Radiology Vol. 29; no. 3; pp. 1094 - 1104 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134415311&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134415311 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2019 vid: 29 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134415311 134415311 NLM30151643 134415311 10.1007/s00330-018-5687-5 NLM30151643 134415311 ppf: 1094 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Characteristics and associated risk factors of diverticular disease assessed by magnetic resonance imaging in subjects from a Western general population. aug: au: Storz, Corinna Rothenbacher, Theresa Rospleszcz, Susanne Linseisen, Jakob Messmann, Helmut De Cecco, Carlo N. Machann, Jürgen Lorbeer, Roberto Kiefer, Lena S. Wintermeyer, Elke Rado, Sophia D. Nikolaou, Konstantin Elser, Stefanie Rathmann, Wolfgang Reiser, Maximilian F. Peters, Annette Schlett, Christopher L. Bamberg, Fabian affil: Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Hoppe-Seyler Str. 3, 72076, Tuebingen, Germany sug: subj: Colon Pathology Magnetic Resonance Imaging Methods Body Mass Index Prevalence Prospective Studies Male Female Middle Age Germany Aged Reproducibility of Results Risk Factors Questionnaires Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Objectives: Diverticular disease represents an increasing pathology and healthcare burden worldwide. Our aim was to study the prevalence, extent and distribution of asymptomatic diverticular disease assessed by magnetic resonance imaging (MRI) in a sample of a Western population.Methods: Subjects from a population-based cohort study who underwent 3-T MRI were analyzed for the prevalence and extent of diverticula of the colon using an isotropic VIBE-Dixon gradient-echo sequence. The extent of diverticular disease was categorized according to the number of diverticula in each colonic segment. Univariate and adjusted analyses were performed to assess associated characteristics and risk factors.Results: Among 393 subjects included in the analysis (56.4 ± 9.2 years, 57.5% males), 164 (42%) had diverticular disease, with the highest prevalence in the left-sided colonic segments (93% diverticular disease in the descending and sigmoid segment). Subjects with advanced diverticular disease were older (62.1 vs. 54.4 years) and had a higher body mass index (BMI), LDL cholesterol levels and systolic blood pressure (30.2 ± 5.1 vs. 27.8 ± 4.9 kg/m2, 149.8 ± 29.3 vs. 135.2 ± 32.9 mg/dl and 128.2 ± 14.1 vs. 118.4 ± 16.1 mmHg, respectively; all p > 0.003) compared with subjects without diverticular disease. In contrast, no significant correlation could be found for gender, physical activity, smoking status and alcohol consumption (all p > 0.31). Intra-rater reliability was excellent for all colonic segments (intra-class correlation [ICC] = 0.99-1.00), and inter-rater reliability was excellent for left- and right-sided colonic segments (ICC = 0.84-0.97).Conclusions: These findings provide insights into the disease mechanism of asymptomatic diverticular disease and may help to improve prevention of diverticulosis and its associated complications.Key Points: • Overall prevalence of asymptomatic diverticular disease assessed by MRI was 42%, affecting predominantly the left-sided colon. • Asymptomatic diverticular disease was associated with age and cardiometabolic risk factors. • Magnetic resonance imaging reveals insights into the pathophysiologic mechanism of asymptomatic diverticular disease. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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