Clear Cell Renal Cell Carcinoma: Machine Learning-Based Quantitative Computed Tomography Texture Analysis for Prediction of Fuhrman Nuclear Grade.
Objective: To evaluate the performance of quantitative computed tomography (CT) texture analysis using different machine learning (ML) classifiers for discriminating low and high nuclear grade clear cell renal cell carcinomas (cc-RCCs).Materials and Methods: This retrospective study included 53 pati...
| Publicado en: | European Radiology Vol. 29; no. 3; pp. 1153 - 1164 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134415319&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134415319 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Mar2019 vid: 29 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134415319 134415319 NLM30167812 134415319 10.1007/s00330-018-5698-2 NLM30167812 134415319 ppf: 1153 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Clear Cell Renal Cell Carcinoma: Machine Learning-Based Quantitative Computed Tomography Texture Analysis for Prediction of Fuhrman Nuclear Grade. aug: au: Bektas, Ceyda Turan Kocak, Burak Yardimci, Aytul Hande Turkcanoglu, Mehmet Hamza Yucetas, Ugur Koca, Sevim Baykal Erdim, Cagri Kilickesmez, Ozgur affil: Department of Radiology, Istanbul Training and Research Hospital, Istanbul, Turkey sug: subj: Algorithms Carcinoma, Renal Cell Diagnosis Kidney Neoplasms Diagnosis Tomography, X-Ray Computed Methods Carcinoma, Renal Cell Surgery Retrospective Design Male Reproducibility of Results Biopsy Adult Middle Age Female Data Collection Aged Diagnosis, Differential Nephrectomy Probability Kidney Neoplasms Surgery Human Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Objective: To evaluate the performance of quantitative computed tomography (CT) texture analysis using different machine learning (ML) classifiers for discriminating low and high nuclear grade clear cell renal cell carcinomas (cc-RCCs).Materials and Methods: This retrospective study included 53 patients with pathologically proven 54 cc-RCCs (31 low-grade [grade 1 or 2]; 23 high-grade [grade 3 or 4]). In one patient, two synchronous cc-RCCs were included in the analysis. Mean age was 57.5 years. Thirty-four (64.1%) patients were male and 19 were female (35.9%). Mean tumour size based on the maximum diameter was 57.4 mm (range, 16-145 mm). Forty patients underwent radical nephrectomy and 13 underwent partial nephrectomy. Following pre-processing steps, two-dimensional CT texture features were extracted using portal-phase contrast-enhanced CT. Reproducibility of texture features was assessed with the intra-class correlation coefficient (ICC). Nested cross-validation with a wrapper-based algorithm was used in feature selection and model optimisation. The ML classifiers were support vector machine (SVM), multilayer perceptron (MLP, a sort of neural network), naïve Bayes, k-nearest neighbours, and random forest. The performance of the classifiers was compared by certain metrics.Results: Among 279 texture features, 241 features with an ICC equal to or higher than 0.80 (excellent reproducibility) were included in the further feature selection process. The best model was created using SVM. The selected subset of features for SVM included five co-occurrence matrix (ICC range, 0.885-0.998), three run-length matrix (ICC range, 0.889-0.992), one gradient (ICC = 0.998), and four Haar wavelet features (ICC range, 0.941-0.997). The overall accuracy, sensitivity (for detecting high-grade cc-RCCs), specificity (for detecting high-grade cc-RCCs), and overall area under the curve of the best model were 85.1%, 91.3%, 80.6%, and 0.860, respectively.Conclusions: The ML-based CT texture analysis can be a useful and promising non-invasive method for prediction of low and high Fuhrman nuclear grade cc-RCCs.Key Points: • Based on the percutaneous biopsy literature, ML-based CT texture analysis has a comparable predictive performance with percutaneous biopsy. • Highest predictive performance was obtained with use of the SVM. • SVM correctly classified 85.1% of cc-RCCs in terms of nuclear grade, with an AUC of 0.860. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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