Exercise-Induced Oxygen Desaturation as a Predictive Factor for Longitudinal Decline in 6-Minute Walk Distance in Subjects With COPD.
BACKGROUND: There are limited longitudinal studies reporting predictive factors for decline in 6-min walk distance (6MWD) in patients with COPD. While previous studies have confirmed the association between air-flow limitation and decline in 6MWD, other factors have not been clarified. The objective...
| Published in: | Respiratory Care Vol. 64; no. 2; pp. 142 - 150 |
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| Main Authors: | , , , , , , |
| Format: | CEU research tables/charts Journal Article |
| Published: |
Mary Ann Liebert, Inc.
Feb2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134551674&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134551674 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Feb2019 vid: 64 iid: 2 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 134551674 134551674 134551674 10.4187/respcare.06169 134551674 ppf: 142 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Exercise-Induced Oxygen Desaturation as a Predictive Factor for Longitudinal Decline in 6-Minute Walk Distance in Subjects With COPD. aug: au: Shogo Misu Masahiro Kaneko Hideki Sakai Yutaro Oki Yukari Fujimoto Akira Ishikawa Rei Ono affil: Department of Community Health Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan sug: subj: Pulmonary Disease, Chronic Obstructive Physiopathology Functional Assessment Methods Exercise Adverse Effects Oxygen Saturation Human Male Female Middle Age Aged Aged, 80 and Over Education, Continuing (Credit) Prospective Studies Nonexperimental Studies Descriptive Statistics Data Analysis Software T-Tests Chi Square Test Two-Way Analysis of Variance Multiple Linear Regression Spirometry Functional Status Pulse Oximetry Lung Volume Measurements Clinical Assessment Tools Scales Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Male Female ab: BACKGROUND: There are limited longitudinal studies reporting predictive factors for decline in 6-min walk distance (6MWD) in patients with COPD. While previous studies have confirmed the association between air-flow limitation and decline in 6MWD, other factors have not been clarified. The objective of this study was to investigate whether exercise-induced oxygen desaturation (EID) could be a predictive factor for decline in 6MWD in patients with COPD. The interactive effect of air-flow limitation on the association between EID and decline in 6MWD was also investigated. METHODS: A longitudinal observational study was conducted with 71 out-patients with COPD who were followed for 1 year. 6MWD, EID, spirometry, and clinical characteristics were assessed. The effect of EID on changes in 6MWD was examined using linear regression analyses. Furthermore, the subjects were categorized into 4 groups according to their EID and air-flow limitation status, and changes in 6MWD were compared among the groups. RESULTS: 51 subjects completed the follow-up assessments, and 29 (56.9%) experienced EID. Multiple linear regression model revealed that EID was the only predictive factor for changes in 6MWD after adjusting for confounders (β = -38.9, P = .02). As results of multiple comparisons among the 4 groups based on EID and air-flow limitation status, changes in 6MWD in the EID and severe air-flow limitation group were the lowest. CONCLUSION: Our results revealed that EID was a predictive factor for decline in the functional capacity of subjects with COPD. The assessment of EID and air-flow limitation would thus be useful in estimating the prognosis of decline in the functional capacity of patients with COPD. pubtype: Academic Journal doctype: CEU research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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