25-Hydroxyvitamin D variability within-person due to diurnal rhythm and illness: a case report.
Background: Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation...
| Published in: | Journal of Medical Case Reports Vol. 13; no. 1 |
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| Main Authors: | , , |
| Format: | case study Journal Article |
| Published: |
BioMed Central
2/4/2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134577675&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134577675 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17521947 8X8Q jtl: Journal of Medical Case Reports issn: 17521947 maglogo: N pubinfo: dt: 2/4/2019 vid: 13 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 134577675 134577675 NLM30712514 134577675 10.1186/s13256-018-1948-9 NLM30712514 134577675 ppct: 1 formats: tig: atl: 25-Hydroxyvitamin D variability within-person due to diurnal rhythm and illness: a case report. aug: au: French, Christine B. McDonnell, Sharon L. Vieth, Reinhold affil: GrassrootsHealth, 315 S. Coast Hwy 101, Suite U-87, 92024, Encinitas, CA, USA sug: subj: Cholecalciferol Administration and Dosage Vitamin D Circadian Rhythm Physiology Common Cold Blood Vitamin D Blood Prospective Studies Dietary Supplements Female Adult Vitamin D Physiology Cholecalciferol Blood Common Cold Physiopathology Adult: 19-44 years Female ab: Background: Vitamin D nutrition research requires accurate measures of circulating 25-hydroxyvitamin D. Our objectives were to test whether a diurnal fluctuation in blood-spot concentrations of 25-hydroxyvitamin D can be demonstrated statistically in a single individual, and whether such fluctuation is affected by the pre-dose versus post-dose timing of the blood draw.Case Presentation: The participant in this case study was a generally healthy Caucasian woman in her 40s who has taken 5000 IU vitamin D3 supplement at midday for over 1 year. Each blood sample was drawn individually from a finger prick onto filter paper at morning, midday, or night, on 4 days (three groups of five individual blood samples per collection day). On days 1 and 2, the midday samples were collected approximately 1 hour after the supplement was taken; on days 3 and 4, the midday samples were collected within an hour prior to supplementation (the classical, daily "trough" value for a drug). There was a significant daily pattern of variation in 25-hydroxyvitamin D concentrations (analysis of variance p ≤ 0.02 for 3 of the 4 days): peak midday mean 25-hydroxyvitamin D was approximately 20% higher than in the morning, and approximately 13% higher than in the evening. Trough sampling produced no significant difference in 25-hydroxyvitamin D compared to sampling an hour after the dose. An incidental finding was that acute illness during the study was related to acutely lower 25-hydroxyvitamin D at every sampling time in the day (p < 0.00001).Conclusions: There was a consistent diurnal variation in 25-hydroxyvitamin D, with the peak at midday. There was no difference between trough versus post-dose blood draws. Acute illness may acutely lower serum 25-hydroxyvitamin D levels. Because within-person, within-day variability in 25-hydroxyvitamin D is approximately 20%, sampling time introduces systematic error in vitamin D nutritional assessment that is bigger than random analytical error or choice of assay method. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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