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Real life outcomes vs. clinical trial results.

Two questions that clinicians should answer as they attempt to apply the results of clinical trials to clinical practice are: (1) will statistically significant results be reproduced in their clinical practice; and (2) if nothing goes wrong in a clinical trial, is everything alright? Regarding the f...

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Published in:Journal of Ophthalmic & Vision Research Vol. 14; no. 1; pp. 88 - 93
Main Author: Zarbin, Marco
Format: pictorial tables/charts Journal Article
Published: Knowledge E DMCC Jan-Mar2019
Online Access:View this record in EBSCOhost
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        atl: Real life outcomes vs. clinical trial results.
      aug:
        au: Zarbin, Marco
        affil: Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Rutgers University, Newark, New Jersey
      sug:
        subj:
          Clinical Trials
          Physicians Psychosocial Factors
          Outcomes Research
          Research Subjects
          Medical Practice, Evidence-Based
          Decision Support Systems, Clinical
      ab: Two questions that clinicians should answer as they attempt to apply the results of clinical trials to clinical practice are: (1) will statistically significant results be reproduced in their clinical practice; and (2) if nothing goes wrong in a clinical trial, is everything alright? Regarding the first question, when considering the results of a randomized, multicenter, prospective, controlled clinical trial, two questions that cannot be addressed by simply by reading the trial results and that only the practicing clinician can answer are: (1) is the study population representative of the patient about to be treated; and (2) is the totality of evidence outside the trial (including the clinician's own extensive experience) consistent with the trial result? Regarding the second question, clinicians are advised to recognize that most studies, even Phase 3 trials, are underpowered to accurately assess the risk of low frequency events.
      pubtype: Academic Journal
      doctype:
        pictorial
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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