Relevance of Topographic Parameters on the Adhesion and Proliferation of Human Gingival Fibroblasts and Oral Bacterial Strains.

Dental implantology allows replacement of failing teeth providing the patient with a general improvement of health. Unfortunately not all reconstructions succeed, as a consequence of the development of infections of bacterial origin on the implant surface. Surface topography is known to modulate a d...

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Publicado en:BioMed Research International pp. 1 - 14
Autores principales: Pacha-Olivenza, Miguel Ángel, Tejero, Ricardo, Fernández-Calderón, María Coronada, Anitua, Eduardo, Troya, María, González-Martín, M. Luisa
Formato: pictorial research tables/charts Journal Article
Publicado: Wiley-Blackwell 2/10/2019
Acceso en línea:Ver este registro en EBSCOhost
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      dt: 2/10/2019
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        10.1155/2019/8456342
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        atl: Relevance of Topographic Parameters on the Adhesion and Proliferation of Human Gingival Fibroblasts and Oral Bacterial Strains.
      aug:
        au:
          Pacha-Olivenza, Miguel Ángel
          Tejero, Ricardo
          Fernández-Calderón, María Coronada
          Anitua, Eduardo
          Troya, María
          González-Martín, M. Luisa
        affil: Department of Biomedical Sciences, Faculty of Medicine, University of Extremadura, Avda de Elvas s/n, 06006 Badajoz, Spain
      sug:
        subj:
          Dental Implants
          Prosthesis-Related Infections Microbiology
          Gingiva Physiology
          Fibroblasts
          Cell Physiology
          Cell Proliferation
          Human
          Agnosia
          Streptococcus Mutans
          Streptococcus
          Gram-Negative Anaerobic Bacteria
          Saliva Analysis
          Acid Etching, Dental
      ab: Dental implantology allows replacement of failing teeth providing the patient with a general improvement of health. Unfortunately not all reconstructions succeed, as a consequence of the development of infections of bacterial origin on the implant surface. Surface topography is known to modulate a differential response to bacterial and mammalian cells but topographical measurements are often limited to vertical parameters. In this work we have extended the topographical measurements also to lateral and hybrid parameters of the five most representative implant and prosthetic component surfaces and correlated the results with bacterial and mammalian cell adhesion and proliferation outcomes. Primary human oral gingival fibroblast (gum cells) and the bacterial strains: Streptococcus mutans, Streptococcus sanguinis and Aggregatibacter actinomycetemcomitans, implicated in infectious processes in the oral/implant environment were employed in the presence or absence of human saliva. The results confirm that even though not all the measured surface is available for bacteria to adhere, the overall race for the surface between cells and bacteria is more favourable to the smoother surfaces (nitrided, as machined or lightly acid etched) than to the rougher ones (strong acid etched or sandblasted/acid etched).
      pubtype: Academic Journal
      doctype:
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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