Safety and feasibility of transcranial direct current stimulation in amyotrophic lateral sclerosis - a pilot study with a single subject experimental design.
Introduction: Transcranial direct current stimulation (tDCS) has been explored as a neuromodulatory tool to prime motor function in several neurological disorders. Studies using tDCS in amyotrophic lateral sclerosis (ALS) are limited. We investigated the safety, feasibility and effects of long-term...
| Publicado en: | Physiotherapy Theory & Practice Vol. 35; no. 5; pp. 458 - 464 |
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| Autores principales: | , , , |
| Formato: | case study clinical trial pictorial research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134651973&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134651973 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09593985 BCJ jtl: Physiotherapy Theory & Practice issn: 09593985 maglogo: Y pubinfo: dt: May2019 vid: 35 iid: 5 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 134651973 134651973 134651973 10.1080/09593985.2018.1443536 134651973 ppf: 458 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Safety and feasibility of transcranial direct current stimulation in amyotrophic lateral sclerosis - a pilot study with a single subject experimental design. aug: au: Madhavan, Sangeetha Sivaramakrishnan, Anjali Bond, Sam Jiang, Qin Li affil: Brain Plasticity Laboratory, Department of Physical Therapy, College of Applied Health Sciences, University of Illinois, Chicago, IL, USA sug: subj: Transcranial Direct Current Stimulation Amyotrophic Lateral Sclerosis Therapy Treatment Outcomes Human Male Adult Clinical Trials Disease Progression Scales Gait Analysis Transcranial Magnetic Stimulation Neurodegenerative Diseases Psychomotor Performance Descriptive Statistics Electromyography Evoked Potentials, Motor Funding Source Clinical Assessment Tools Muscle Strength Muscle Spasticity Outcome Assessment Adult: 19-44 years Male ab: Introduction: Transcranial direct current stimulation (tDCS) has been explored as a neuromodulatory tool to prime motor function in several neurological disorders. Studies using tDCS in amyotrophic lateral sclerosis (ALS) are limited. We investigated the safety, feasibility and effects of long-term tDCS in an individual with ALS. Methods: A 36-year-old male diagnosed with clinically definite ALS received 12 sessions each of anodal, sham, and cathodal tDCS. Outcome measures included disease progression (revised ALS functional rating scale (ALSFRS-R)), clinical measures of endurance and mobility, and corticomotor excitability. Results: No adverse events or change in disease progression were noticed during the study. Small improvement in gait speed (15% increase) was noticed with anodal tDCS only. Conclusions: This case study demonstrates the safety and feasibility of long-term facilitatory and inhibitory tDCS on a single participant with ALS. This study serves as a guideline for implementing tDCS in future ALS trials. pubtype: Academic Journal doctype: case study clinical trial pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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