CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB.
Background: Metastasis is the major cause of death from breast cancer. Colonization and adaption of metastatic cells in distant organs is a rate-limiting step of the cancer spreading. The underlying mechanisms responsible for the colonization of breast cancer to lung metastatic niches are not fully...
| Published in: | Breast Cancer Research Vol. 21; no. 1 |
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| Main Authors: | , , , , , , |
| Format: | research Journal Article |
| Published: |
BioMed Central
2/12/2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134666582&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134666582 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14655411 8UYJ jtl: Breast Cancer Research issn: 14655411 maglogo: N pubinfo: dt: 2/12/2019 vid: 21 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 134666582 134666582 NLM30755260 134666582 10.1186/s13058-019-1114-3 NLM30755260 134666582 ppct: 1 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: CXCL17-derived CD11b+Gr-1+ myeloid-derived suppressor cells contribute to lung metastasis of breast cancer through platelet-derived growth factor-BB. aug: au: Hsu, Ya-Ling Yen, Meng-Chi Chang, Wei-An Tsai, Pei-Hsun Pan, Yi-Chung Liao, Ssu-Hui Kuo, Po-Lin affil: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 807, Kaohsiung, Taiwan sug: subj: Chemokines Metabolism Breast Neoplasms Pathology Lung Neoplasms Pathology Cytokines Metabolism Kaplan-Meier Estimator Human Breast Neoplasms Blood Receptors, Cell Surface Metabolism Animal Studies Prognosis Cell Physiology Breast Neoplasms Mortality Female Chemokines Blood Data Collection Lung Pathology Cell Line, Tumor Mice Breast Neoplasms Immunology Lung Neoplasms Validation Studies Comparative Studies Evaluation Research Multicenter Studies Female ab: Background: Metastasis is the major cause of death from breast cancer. Colonization and adaption of metastatic cells in distant organs is a rate-limiting step of the cancer spreading. The underlying mechanisms responsible for the colonization of breast cancer to lung metastatic niches are not fully understood.Methods: Specific gene contributions to lung metastasis were identified by comparing gene profiles of 4T1 tumors metastasizing to various organs via microarray. The oncogenic properties CXCL17 were examined by in vivo spontaneous metastasis mouse model. The chemotactic activity of CXCL17 on CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) was examined by both in vitro and in vivo models. The therapeutic effects of MDSC depletion and platelet-derived growth factor-BB (PDGF-BB) inhibition were examined by orthotic models.Results: Here, we demonstrate that breast cancer cells secrete CXCL17, which increases the accumulation of CD11b+Gr-1+ MDSCs in the lungs. Metastatic lung-infiltrating CD11b+Gr-1+ MDSCs induce angiogenesis in the lungs and facilitate cancer extravasation and survival that ultimately promote lung metastases. CXCL17 increases CD11b+Gr-1+ MDSCs to express PDGF-BB, which not only contributes to CD11b+Gr-1+ MDSC-mediated angiogenesis in the lung metastatic niche, but is also involved in the colonization of breast cancer. Consequently, both CD11b+Gr-1+ MDSC depletion and PDGF receptor inhibitor effectively prevents CXCL17-driven lung metastasis in breast cancer. More importantly, patients with high levels of CXCL17 have shorter distant metastasis-free and overall survival rates, indicators of poor prognosis.Conclusion: Our study reveals that MDSCs derived by CXCL17 contribute to the establishment of a lung metastatic niche by PDGF-BB secretion and provide a rationale for development of CXCL17 or PDGF-BB antagonists to inhibit or prevent lung metastasis in cases of breast cancer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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