Predicting extinction phenotype to optimize fear reduction.
Fear conditioning is widely employed to study dysregulations of the fear system. The repeated presentation of a conditioned stimulus in the absence of a reinforcer leads to a decrease in fear responding—a phenomenon known as extinction. From a translational perspective, identifying whether an indivi...
| Publicado en: | Psychopharmacology Vol. 236; no. 1; pp. 99 - 111 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134695227&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134695227 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jan2019 vid: 236 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134695227 10.1007/s00213-018-5005-6 134695227 ppf: 99 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Predicting extinction phenotype to optimize fear reduction. aug: au: Monfils, M. H. Lee, H. J. Keller, N. E. Roquet, R. F. Quevedo, S. Agee, L. Cofresi, R. Shumake, J. affil: Department of Psychology, University of Texas at Austin, Austin, TX, USA sug: ab: Fear conditioning is widely employed to study dysregulations of the fear system. The repeated presentation of a conditioned stimulus in the absence of a reinforcer leads to a decrease in fear responding—a phenomenon known as extinction. From a translational perspective, identifying whether an individual might respond well to extinction prior to intervention could prove important to treatment outcomes. Here, we test the hypothesis that CO2 reactivity predicts extinction phenotype in rats, and that variability in CO2 reactivity as well as extinction long-term memory (LTM) significantly predicts orexin activity in the lateral hypothalamus (LH). Our results validate a rat model of CO2 reactivity and show that subcomponents of behavioral reactivity following acute CO2 exposure explain a significant portion of the variance in extinction LTM. Furthermore, we show evidence that variability in CO2 reactivity is also significantly predictive of orexin activity in the LH, and that orexin activity, in turn, significantly accounts for LTM variance. Our findings open the possibility that we may be able to use CO2 reactivity as a screening tool to determine if individuals are good candidates for an extinction/exposure-based approach. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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