Mechanisms of fear learning and extinction: synaptic plasticity-fear memory connection.
Rationale: The ability to memorize threat-associated cues and subsequently react to them, exhibiting escape or avoidance responses, is an essential, often life-saving behavioral mechanism that can be experimentally studied using the fear (threat) conditioning training paradigm. Presently, there is s...
| Publicado en: | Psychopharmacology Vol. 236; no. 1; pp. 163 - 183 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Jan2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134695251&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134695251 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jan2019 vid: 236 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134695251 10.1007/s00213-018-5104-4 134695251 ppf: 163 ppct: 20 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Mechanisms of fear learning and extinction: synaptic plasticity-fear memory connection. aug: au: Luchkina, Natalia V. Bolshakov, Vadim Y. affil: Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, 02478, Belmont, MA, USA sug: ab: Rationale: The ability to memorize threat-associated cues and subsequently react to them, exhibiting escape or avoidance responses, is an essential, often life-saving behavioral mechanism that can be experimentally studied using the fear (threat) conditioning training paradigm. Presently, there is substantial evidence supporting the Synaptic Plasticity-Memory (SPM) hypothesis in relation to the mechanisms underlying the acquisition, retention, and extinction of conditioned fear memory.Objectives: The purpose of this review article is to summarize findings supporting the SPM hypothesis in the context of conditioned fear control, applying the set of criteria and tests which were proposed as necessary to causally link lasting changes in synaptic transmission in corresponding neural circuits to fear memory acquisition and extinction with an emphasis on their pharmacological diversity.Results: The mechanisms of synaptic plasticity in fear circuits exhibit complex pharmacological profiles and satisfy all four SPM criteria—detectability, anterograde alteration, retrograde alteration, and mimicry.Conclusion: The reviewed findings, accumulated over the last two decades, provide support for both necessity and sufficiency of synaptic plasticity in fear circuits for fear memory acquisition and retention, and, in part, for fear extinction, with the latter requiring additional experimental work. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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