Tuberculosis-associated hemophagocytic lymphohistiocytosis with subsequent unmasking cryptococcal immune reconstitution inflammatory syndrome (IRIS) in an HIV-negative man.
A 22-year-old HIV-negative man from Ghana was diagnosed with severe hemophagocytic lymphohistiocytosis (HLH) induced by multiorgan tuberculosis with peritoneal, hepatic, pericardial, myocardial, pleural, pulmonary, and bone manifestation. His body mass index was 12.9 m2/kg. Bioptic material of a per...
| Publicado en: | Infection Vol. 47; no. 1; pp. 129 - 134 |
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| Autores principales: | , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134717383&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134717383 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03008126 NXO jtl: Infection issn: 03008126 maglogo: N pubinfo: dt: Feb2019 vid: 47 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134717383 134717383 134717383 10.1007/s15010-018-1226-1 134717383 ppf: 129 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Tuberculosis-associated hemophagocytic lymphohistiocytosis with subsequent unmasking cryptococcal immune reconstitution inflammatory syndrome (IRIS) in an HIV-negative man. aug: au: Geerdes-Fenge, Hilte F. Löbermann, Micha Hemmer, Christoph J. Benedek, Orsolya Reisinger, Emil C. affil: Department of Tropical Medicine and Infectious Diseases, Rostock University Medical Center, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany sug: subj: Hemophagocytic Lymphohistiocytosis Etiology Tuberculosis Complications Hemophagocytic Lymphohistiocytosis Diagnosis HIV Infections Diagnosis Immune Reconstitution Inflammatory Syndrome Diagnosis Tuberculosis Diagnosis Young Adult Male Ghana Body Mass Index Biopsy Methods Antitubercular Agents Therapeutic Use Tuberculosis Drug Therapy Tomography, X-Ray Computed Hemophagocytic Lymphohistiocytosis Drug Therapy Magnetic Resonance Imaging Antifungal Agents Therapeutic Use Spinal Puncture Male ab: A 22-year-old HIV-negative man from Ghana was diagnosed with severe hemophagocytic lymphohistiocytosis (HLH) induced by multiorgan tuberculosis with peritoneal, hepatic, pericardial, myocardial, pleural, pulmonary, and bone manifestation. His body mass index was 12.9 m2/kg. Bioptic material of a peritoneal biopsy grew M. tuberculosis, sensitive to all first-line antituberculous drugs. HLH resolved with antituberculous therapy, without additional anti-inflammatory therapy being given. The initial CT scan of his brain was normal. After 5 months of antituberculous treatment, he developed a paralysis of the left arm. A cerebral MRT showed ring-enhanced lesions. Blood cultures and lumbar puncture revealed Cryptococcus neoformans var. grubi. The HIV test was repeatedly negative. Antituberculous treatment was continued for a total of 9 months, and additional treatment with antifungal therapy was established. He recovered fully after 14 months of antifungal treatment. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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