Correlation of bone marrow cellularity and metabolic activity in healthy volunteers with simultaneous PET/MR imaging.
Objective: To evaluate the correlation between bone marrow cellularity (BMC) and metabolic activity in healthy subjects and to see whether yellow marrow is indeed metabolically quiescent. Because metabolic activity can be assumed to reflect vascularity, we assessed the relationship between regional...
| Publicado en: | Skeletal Radiology Vol. 48; no. 4; pp. 527 - 535 |
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| Autores principales: | , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134766286&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134766286 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03642348 O14 jtl: Skeletal Radiology issn: 03642348 maglogo: N pubinfo: dt: Apr2019 vid: 48 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134766286 134766286 NLM30194581 10.1007/s00256-018-3058-6 NLM30194581 134766286 ppf: 527 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Correlation of bone marrow cellularity and metabolic activity in healthy volunteers with simultaneous PET/MR imaging. aug: au: Fukuda, Takeshi Huang, Mingqian Janardhanan, Anuradha Schweitzer, Mark E. Huang, Chuan affil: Department of Radiology, Stony Brook University, Stony Brook, NY, USA sug: subj: Diagnostic Imaging Research Subjects Bone Marrow Metabolism Femur Tomography, Emission-Computed Male Magnetic Resonance Imaging Prospective Studies Female Adult Image Processing, Computer Assisted Pelvic Bones Adult: 19-44 years Male Female ab: Objective: To evaluate the correlation between bone marrow cellularity (BMC) and metabolic activity in healthy subjects and to see whether yellow marrow is indeed metabolically quiescent. Because metabolic activity can be assumed to reflect vascularity, we assessed the relationship between regional metabolic activity and geographic frequency of metastases as noted in the literature.Materials and Methods: Two hundred and twenty locations (ten in each side of the pelvis and proximal femur) were evaluated in 11 consecutive healthy volunteers with simultaneous PET/MR. BMC was calculated through precise water-fat fraction quantification with a 6-echo gradient echo. We analyzed correlations between cellularity and SUVr, age, and R2*. We also looked at the relation between our results and the reported prevalence of metastases.Results: There was moderate but statistically significant correlation between BMC and metabolic activity (r = 0.636, p < 0.0001). Interestingly, the iliac and sacrum had higher metabolic activity relative to cellularity, whereas the femoral neck and lesser trochanter showed lower SUVr than other regions with the similar cellularity. The relatively lower metabolic status of the femoral neck conflicted with its reported high frequency of metastasis. Excluding regions with almost no remaining red marrow, cellularity showed inverse relationship with age (r = 0.476, p < 0.0001) and direct relationship with R2* (r = 0.532, p < 0.0010).Conclusions: Metabolic activity of bone marrow was largely dependent on BMC while yellow marrow seems metabolically quiescent. The discrepancy between the assumed vascularity as determined by metabolic activity and reported sites of metastasis suggested that the process of bone metastasis may not depend entirely on vascularity. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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