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Initial experience with dual-energy computed tomography-guided bone biopsies of bone lesions that are occult on monoenergetic CT.

Objective: Our purpose was to determine whether dual-energy CT (DECT), specifically the bone marrow setting of the virtual noncalcium (VNCa) algorithm, could be used to identify and accurately biopsy suspected bone malignancies that were visible on magnetic resonance imaging (MRI), nuclear bone scin...

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Published in:Skeletal Radiology Vol. 48; no. 4; pp. 605 - 614
Main Authors: Burke, Michael C., Garg, Ankur, Youngner, Jonathan M., Deshmukh, Swati D., Omar, Imran M.
Format: case study Journal Article
Published: Springer Nature Apr2019
Online Access:View this record in EBSCOhost
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      dt: Apr2019
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s00256-018-3087-1
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        atl: Initial experience with dual-energy computed tomography-guided bone biopsies of bone lesions that are occult on monoenergetic CT.
      aug:
        au:
          Burke, Michael C.
          Garg, Ankur
          Youngner, Jonathan M.
          Deshmukh, Swati D.
          Omar, Imran M.
        affil: Department of Radiology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 800, 60611, Chicago, IL, USA
      sug:
        subj:
          Bone Neoplasms
          Biopsy
          Tomography, X-Ray Computed Methods
          Aged
          Radiographic Image Interpretation, Computer-Assisted
          Magnetic Resonance Imaging
          Algorithms
          Female
          Male
          Retrospective Design
          Aged, 80 and Over
          Contrast Media
          Aged: 65+ years
          Aged, 80 & over
          Female
          Male
      ab: Objective: Our purpose was to determine whether dual-energy CT (DECT), specifically the bone marrow setting of the virtual noncalcium (VNCa) algorithm, could be used to identify and accurately biopsy suspected bone malignancies that were visible on magnetic resonance imaging (MRI), nuclear bone scintigraphy, or positron-emission tomography/computed tomography (PET/CT), but occult on monoenergetic computed tomography (CT) by virtue of being either isodense or nearly isodense to surrounding normal bone.Materials and Methods: We present 4 cases in which DECT was used to detect various malignant bone lesions and was successfully used to direct percutaneous DECT-guided bone biopsies.Results: Two of the lesions were solid tumor metastases (breast and prostate carcinoma), whereas two others were hematological malignancies (leukemia and lymphoma). This technique enabled us to confidently and accurately direct the biopsy needle into the target lesion.Conclusion: The authors demonstrate that the DECT VNCa bone marrow algorithm may be helpful in identifying isodense bone lesions of various histologies and may be used to guide percutaneous bone biopsies. This technique may help to maximize diagnostic yield, minimize the number of passes into the region of concern, and prevent patients from undergoing repeat biopsy.
      pubtype: Academic Journal
      doctype:
        case study
        Journal Article
      ougenre: Article
    language: English
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