Metabolic Imaging Phenotype Using Radiomics of [18F]FDG PET/CT Associated with Genetic Alterations of Colorectal Cancer.
Purpose: To understand the association between genetic mutations and radiomics of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT) in patients with colorectal cancer (CRC).Procedures: This study included 74 CRC patients who had undergone pr...
| Publicado en: | Molecular Imaging & Biology Vol. 21; no. 1; pp. 183 - 191 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134786717&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134786717 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15361632 KJU jtl: Molecular Imaging & Biology issn: 15361632 maglogo: N pubinfo: dt: Feb2019 vid: 21 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134786717 134786717 NLM29948642 134786717 10.1007/s11307-018-1225-8 NLM29948642 134786717 ppf: 183 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Metabolic Imaging Phenotype Using Radiomics of [18F]FDG PET/CT Associated with Genetic Alterations of Colorectal Cancer. aug: au: Chen, Shang-Wen Shen, Wei-Chih Chen, William Tzu-Liang Hsieh, Te-Chun Yen, Kuo-Yang Chang, Jan-Gowth Kao, Chia-Hung affil: Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan sug: subj: Mutation Physiology Metabolism Colorectal Neoplasms Metabolism Colorectal Neoplasms Fludeoxyglucose F 18 Pharmacokinetics Metabolism Radiation Effects Colorectal Neoplasms Diagnosis Adult Aged Dose-Response Relationship, Radiation Phenotype Aged, 80 and Over Human Colorectal Neoplasms Pathology Sequence Analysis Methods Pilot Studies Radiometry Methods Male Retrospective Design Middle Age Female Funding Source Adult: 19-44 years Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Male Female ab: Purpose: To understand the association between genetic mutations and radiomics of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/x-ray computed tomography (CT) in patients with colorectal cancer (CRC).Procedures: This study included 74 CRC patients who had undergone preoperative [18F]FDG PET/CT. A total of 65 PET/CT-related features including intensity, volume-based, histogram, and textural features were calculated. High-resolution melting methods were used for genetic mutation analysis.Results: Genetic mutants were found in 21 KRAS tumors (28 %), 31 TP53 tumors (42 %), and 17 APC tumors (23 %). Tumors with a mutated KRAS had an increased value at the 25th percentile of maximal standardized uptake value (SUVmax) within their metabolic tumor volume (MTV) (P < .0001; odds ratio [OR] 1.99; 95 % confidence interval [CI] 1.37-2.90) and their contrast from the gray-level cooccurrence matrix (P = .005; OR 1.52; 95 % CI 1.14-2.04). A mutated TP53 was associated with an increased value of short-run low gray-level emphasis derived from the gray-level run length matrix (P = .001; OR 243006.0; 95 % CI 59.2-996,872,313). APC mutants exhibited lower low gray-level zone emphasis derived from the gray-level zone length matrix (P = .006; OR < .0001; 95 % CI 0.000-0.22).Conclusion: PET/CT-derived radiomics can provide supplemental information to determine KRAS, TP53, and APC genetic alterations in CRC. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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