Reference-less MR thermometry on pre-clinical thiel human cadaver for liver surgery with MRgFUS.

Purpose: Reference-less MR thermometry can be a promising technique for temperature mapping during liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS), as it is more robust to breathing motion than Proton Resonance Frequency MR thermometry. However, there is a lack of a pre-cl...

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Publicado en:Minimally Invasive Therapy & Allied Technologies Vol. 28; no. 1; pp. 15 - 22
Autores principales: Karakitsios, Ioannis, Mihcin, Senay, Melzer, Andreas
Formato: diagnostic images equations & formulas research tables/charts Journal Article
Publicado: Taylor & Francis Ltd Fe2019
Acceso en línea:Ver este registro en EBSCOhost
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      pub: Taylor & Francis Ltd
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        10.1080/13645706.2018.1470985
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        atl: Reference-less MR thermometry on pre-clinical thiel human cadaver for liver surgery with MRgFUS.
      aug:
        au:
          Karakitsios, Ioannis
          Mihcin, Senay
          Melzer, Andreas
        affil: Institute for Medical Science and Technology, University of Dundee, Dundee, Scotland, UK
      sug:
        subj:
          Liver Surgery
          Cadaver
          Thermometers
          Magnetic Resonance Imaging Methods
          Ultrasonography Methods
          Human
          Algorithms
      ab: Purpose: Reference-less MR thermometry can be a promising technique for temperature mapping during liver treatment with Magnetic Resonance-guided Focused Ultrasound (MRgFUS), as it is more robust to breathing motion than Proton Resonance Frequency MR thermometry. However, there is a lack of a pre-clinical model for repeatable testing of reference-less thermometry. The purpose of this work was to verify the explanted Thiel embalmed human liver and whole Thiel embalmed human cadaver for application of a custom made reference-less thermometry algorithm during MRgFUS sonication. Material and methods: Phase maps were generated during sonication as an input to the algorithm. A square Region-of-Interest (ROI) was designed around the heated area. The ROI was interpolated using a two-dimensional polynomial to the surrounding phase map to calculate the background phase. Results: Using the phase information from the images, the temperature rise was measured. Validation of the methodology showed accordance of temperatures with actual temperatures. Conclusions: The explanted liver and the whole cadaver constitute a promising and feasible model to study reference-less techniques for thermometry during MRgFUS, before clinical trials.
      pubtype: Academic Journal
      doctype:
        diagnostic images
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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