Benefits and risks of protocol biopsies in pediatric renal transplantation.
Protocol biopsies are defined as sampling of allograft tissue at predetermined times regardless of function. This procedure can be justified due to the lack of non-invasive methods to reliably diagnose rejection (acute or subclinical). Changes in creatinine are not seen with subclinical rejection or...
| Publicado en: | Pediatric Nephrology Vol. 34; no. 4; pp. 593 - 599 |
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| Autores principales: | , , , , |
| Formato: | diagnostic images exam questions review Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=134918568&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 134918568 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Apr2019 vid: 34 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 134918568 134918568 134918568 10.1007/s00467-018-3959-6 134918568 ppf: 593 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Benefits and risks of protocol biopsies in pediatric renal transplantation. aug: au: Gordillo, Roberto Munshi, Raj Monroe, Eric J. Shivaram, Giridhar M. Smith, Jodi M. affil: Division of Nephrology, Seattle Children's Hospital, University of Washington, Seattle, WA, USA sug: subj: Biopsy Kidney Transplantation Allografts Pediatric Care Risk Assessment Protocols Graft Rejection Creatinine Blood Graft Survival ab: Protocol biopsies are defined as sampling of allograft tissue at predetermined times regardless of function. This procedure can be justified due to the lack of non-invasive methods to reliably diagnose rejection (acute or subclinical). Changes in creatinine are not seen with subclinical rejection or early acute rejection and do not always correlate with efficacy of treatment. Parents and providers are still hesitant to pursue protocol biopsy due to the potential complications and lack of definitive evidence of a benefit from doing this procedure. Importantly, the rate of transplant renal biopsy complications requiring additional intervention is low. It is unclear if detection and treatment of subclinical rejection detected on protocol biopsy will lead to improved graft survival. Our goal is to review the literature on this topic and share some of the experience in our center. Definition, indications, and complications of diagnostic transplant renal biopsies are not included in this review. pubtype: Academic Journal doctype: diagnostic images exam questions review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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