Correlation between geometric parameters of the left coronary artery and hemodynamic descriptors of atherosclerosis: FSI and statistical study.
The hemodynamics conditioned by coronary geometry may play an important role in the creation of a pro-atherogenic environment in specific locations of the coronary tree. The aim of this study is to identify how several geometric parameters of the left coronary artery - cross-section areas, proximal...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 57; no. 3; pp. 715 - 730 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135086829&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135086829 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Mar2019 vid: 57 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135086829 135086829 NLM30357605 10.1007/s11517-018-1904-2 NLM30357605 135086829 ppf: 715 ppct: 15 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Correlation between geometric parameters of the left coronary artery and hemodynamic descriptors of atherosclerosis: FSI and statistical study. aug: au: Pinho, N. Castro, C. F. António, C. C. Bettencourt, N. Sousa, L. C. Pinto, S. I. S. affil: Institute of Science and Innovation in Mechanical and Industrial Engineering (INEGI), Engineering Faculty, University of Porto, Rua Dr. Roberto Frias s/n, 4200 - 465, Porto, Portugal sug: subj: Models, Biological Atherosclerosis Physiopathology Coronary Vessels Anatomy and Histology Middle Age Coronary Vessels Physiology Adult Female Image Processing, Computer Assisted Male Coronary Vessels Physiopathology Computer Simulation Statistics and Numerical Data Hemodynamics Middle Aged: 45-64 years Adult: 19-44 years Female Male ab: The hemodynamics conditioned by coronary geometry may play an important role in the creation of a pro-atherogenic environment in specific locations of the coronary tree. The aim of this study is to identify how several geometric parameters of the left coronary artery - cross-section areas, proximal left anterior descending artery length, angles between the branches and the septum, curvature and tortuosity - can be related with hemodynamic descriptors, using a computational fluid-structure interaction method. It is widely accepted that the hemodynamic indicators play an important role in identifying possible pro-atherogenic locations. A statistical study, using Pearson correlation coefficient and P value, was performed for a population study of 8 normal human left coronary arteries presenting right-dominant circulation. Within the study cases, arteries with high caliber (r = 0.88), high angles LMS-LAD (r = 0.49), LAD-LCx (r = 0.57) and LAD-Septum (r = 0.52), and high tortuosity LMS-LCx (r = 0.63) were correlated with a hemodynamic behavior propitious to plaque formation in the left anterior descending artery. In contrast, high proximal left anterior descending artery length (r = -0.41), high angle LMS-LCx (r = -0.59), high tortuosity LMS-LAD (r = -0.56) and LAD-LCx (r = -0.55) and high curvature of LMS (r = -0.60) and LCx (r = -0.56) can lead to non-favorable hemodynamic conditions for atheroma formation. Graphical abstract. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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