The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063).
The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalize...
| Publicado en: | AIDS & Behavior Vol. 23; no. 3; pp. 649 - 661 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135148353&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135148353 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10907165 G1T jtl: AIDS & Behavior issn: 10907165 maglogo: N pubinfo: dt: Mar2019 vid: 23 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135148353 135148353 135148353 10.1007/s10461-019-02415-w 135148353 ppf: 649 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: The Longitudinal Effects of Non-injection Substance Use on Sustained HIV Viral Load Undetectability Among MSM and Heterosexual Men in Brazil and Thailand: The Role of ART Adherence and Depressive Symptoms (HPTN 063). aug: au: Tsuyuki, Kiyomi Shoptaw, Steven J. Ransome, Yusuf Chau, Gordon Rodriguez-Diaz, Carlos E. Friedman, Ruth K. Srithanaviboonchai, Kriengkrai Li, Sue Mimiaga, Matthew J. Mayer, Kenneth H. Safren, Steven A. affil: Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), 9500 Gilman Drive, MC 0507, La Jolla, 92093-0507, San Diego, CA, USA sug: subj: Substance Abuse, Intravenous Viral Load Heterosexuals Thailand Men Who Have Sex With Men Psychosocial Factors HIV Infections Drug Therapy Anti-Retroviral Agents Therapeutic Use Medication Compliance Depression Human Prospective Studies Brazil Thailand Nonexperimental Studies Zambia Cannabis Alcohol Abuse Odds Ratio Confidence Intervals Male Male ab: The effect of non-injection substance use on HIV viral load (VL) is understudied in international settings. Data are from HPTN063, a longitudinal observational study of HIV-infected individuals in Brazil, Thailand, and Zambia, with focus on men with VL data (Brazil = 146; Thailand = 159). Generalized linear mixed models (GLMM) assessed whether non-injection substance use (stimulants, cannabis, alcohol, polysubstance) was associated with VL undetectability. ART adherence and depressive symptoms were examined as mediators of the association. In Thailand, substance use was not significantly associated with VL undetectability or ART adherence, but alcohol misuse among MSM was associated with increased odds of depression (AOR = 2.75; 95% CI 1.20, 6.32, p = 0.02). In Brazil, alcohol misuse by MSM was associated with decreased odds of undetectable VL (AOR = 0.34; 95% CI 0.13, 0.92, p = 0.03). Polysubstance use by heterosexual men in Brazil was associated with decreased odds of ART adherence (AOR = 0.25; 95% CI 0.08, 0.78, p = 0.02). VL suppression appears attainable among non-injection substance users. Substance use interventions among HIV-positive men should address depression, adherence, and VL undetectability. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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