Validation of the Semiautomatic Quantification of 18F-Fluoride PET/CT Whole-Body Skeletal Tumor Burden.
Our purpose was to validate a semiautomatic quantification of the skeletal tumor burden on 18F-fluoride PET/CT using manual quantification as a reference. Methods: We quantified 51 18F-fluoride PET/CT examinations performed on female breast cancer patients. Clinical information (age; time of disease...
| Published in: | Journal of Nuclear Medicine Technology Vol. 46; no. 4; pp. 378 - 384 |
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| Main Authors: | , , , , , , |
| Format: | research Journal Article |
| Published: |
Society of Nuclear Medicine
Dec2018
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135225227&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135225227 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00914916 H7Q jtl: Journal of Nuclear Medicine Technology issn: 00914916 maglogo: N pubinfo: dt: Dec2018 vid: 46 iid: 4 pid: 2576 pub: Society of Nuclear Medicine place: Reston, Virginia artinfo: ui: 135225227 135225227 NLM30076246 135225227 10.2967/jnmt.118.211474 NLM30076246 135225227 ppf: 378 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Validation of the Semiautomatic Quantification of 18F-Fluoride PET/CT Whole-Body Skeletal Tumor Burden. aug: au: Brito, Ana E. Mourato, Felipe Santos, Allan Mosci, Camila Ramos, Celso Etchebehere, Elba Brito, Ana Emília Teixeira affil: Real Nuclear of Real Hospital Português de Beneficência em Pernambuco, Recife, Brazil sug: subj: Fluorides Bone Neoplasms Body Weights and Measures Fluorine Radioisotopes Bone Neoplasms Pathology Human Female Automation Breast Neoplasms Pathology Image Processing, Computer Assisted Validation Studies Comparative Studies Evaluation Research Multicenter Studies Female ab: Our purpose was to validate a semiautomatic quantification of the skeletal tumor burden on 18F-fluoride PET/CT using manual quantification as a reference. Methods: We quantified 51 18F-fluoride PET/CT examinations performed on female breast cancer patients. Clinical information (age; time of disease presentation; presence of visceral metastases; and time to death, progression, or a bone event) was recorded. The total volume of 18F-fluoride-avid skeletal metastases and the total activity of 18F-fluoride-avid metastases were calculated manually and semiautomatically. Results: Manual and semiautomatic metrics correlated strongly (P < 0.0001; 95% confidence interval, 0.9300-0.9769). On multivariable analysis, the semiautomatic measures of total activity for 18F-fluoride-avid metastasis correlated significantly with overall survival (P = 0.0001) and progression-free survival (P = 0.0006). Approximate times for calculating skeletal tumor burden (semiautomatic vs. manual) were, respectively, 30 s versus 321 s in patients with fewer than 5 metastases, 120 s versus 640 s in patients with 5-10 metastases, and 240 s versus 1207s in patients with more than 10 metastases. Conclusion: Semiautomatic quantification of whole-body 18F-fluoride PET/CT skeletal tumor burden can replace manual quantification in breast cancer patients and is a strong independent biomarker of prognosis. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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