A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice.
Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order to understand the molecular mechanisms of adiposis, the changes of physiological, pathological, epigenetic and correlative gene expression were investigated during the adiposis development of C57BL...
| Publicado en: | Physiological Research Vol. 68; no. 1; pp. 75 - 88 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Institute of Physiology, Academy of Sciences of the Czech Republic
2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135231054&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135231054 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08628408 1CVW jtl: Physiological Research issn: 08628408 maglogo: N pubinfo: dt: 2019 vid: 68 iid: 1 pid: 24634 pub: Institute of Physiology, Academy of Sciences of the Czech Republic artinfo: ui: 135231054 10.33549/physiolres.933830 135231054 ppf: 75 ppct: 13 formats: fmt: @attributes: type: P tig: atl: A Study on Molecular Mechanisms of Adiposis Induced by Long-Term Treatment of High-Fat and High-Sucrose in C57BL/6J Mice. aug: au: Xiaodan LI Peipei TU UMAR, Muhammad Qiqi LIU Wenya LUO Xingkai YANG Jianghong ZHU Deling KONG Minggang LI affil: State Key Laboratory of Medical Chemical Biology, Key Laboratory for Bioactive Materials of the Ministry of Education, College of Life Science, Nankai University, Tianjin, China sug: ab: Adiposis is reputed as a twin disease of type 2 diabetes and greatly harmful to human health. In order to understand the molecular mechanisms of adiposis, the changes of physiological, pathological, epigenetic and correlative gene expression were investigated during the adiposis development of C57BL/6J mice induced by long time (9 months) high-fat and high-sucrose diet (HFSD) sustainably. The results showed that mRNA transcription level of the Leptin, Glut4 and Glut2 genes have been obviously changed, which exhibit a negative correlation with methylation on their promoter DNA. The results also revealed that HFSD induced higher level of DNA methyltransferase 1 (DNMT1) in fat tissue might play important role in regulating the changes of methylation pattern on Glut4 and Leptin genes, and which might be one of the molecular mechanisms for the adiposis development. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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