Neural correlates of emotional valence processing in Parkinson's disease: dysfunction in the subcortex.
Parkinson's disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 1; pp. 189 - 200 |
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| Autores principales: | , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135233767&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135233767 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2019 vid: 13 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135233767 135233767 NLM28812218 10.1007/s11682-017-9754-3 NLM28812218 135233767 ppf: 189 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neural correlates of emotional valence processing in Parkinson's disease: dysfunction in the subcortex. aug: au: Bell, Peter T. Gilat, Moran Shine, James M. McMahon, Katie L. Lewis, Simon J. G. Copland, David A. affil: Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia sug: subj: Parkinson Disease Physiopathology Parkinson Disease Psychosocial Factors Brain Physiopathology Emotions Brain Parkinson Disease Male Magnetic Resonance Imaging Aged Brain Mapping Female Behavior Clinical Assessment Tools Aged: 65+ years Male Female ab: Parkinson's disease (PD) is frequently accompanied by cognitive and neuropsychiatric symptoms including impairments in affective processing. Despite this, mechanisms underlying vulnerability to deficits in affective processing remain unclear. In this study, we utilized functional Magnetic Resonance Imaging (fMRI) and an Affective Go-NoGo paradigm, to examine the neural correlates of emotional valence processing in PD. Results suggest that PD is associated with aberrant processing of emotional valence in subcortical limbic structures. Specifically, we found significant group-by-valence interactions in the ventral striatum and amygdala in response to words of differing emotional valence. Our findings contribute to a broader understanding of affective processing in PD and may provide insights into the mechanisms underlying vulnerability to mood disorders in PD. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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