Identify a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer's pathology.
Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD)-associated neurodegeneration. However, NPS lack a consistent relationship with AD pathology. It is unknown whether any common neural circuits can link these clinically disparate while mechanistically similar features with AD path...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 1; pp. 53 - 65 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135233769&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135233769 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2019 vid: 13 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135233769 135233769 NLM28913718 10.1007/s11682-017-9767-y NLM28913718 135233769 ppf: 53 ppct: 12 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Identify a shared neural circuit linking multiple neuropsychiatric symptoms with Alzheimer's pathology. aug: au: Wang, Xixi Ren, Ping Mapstone, Mark Conwell, Yeates Porsteinsson, Anton P. Foxe, John J. Raizada, Rajeev D. S. Lin, Feng and the Alzheimer's Disease Neuroimaging Initiative affil: Department of Biomedical Engineering, University of Rochester, 14627, Rochester, NY, USA sug: subj: Alzheimer's Disease Physiopathology Brain Physiopathology Mental Disorders Physiopathology Brain Male Multivariate Analysis Nerve Tissue Proteins Cerebrospinal Fluid Magnetic Resonance Imaging Methods Alzheimer's Disease Neural Pathways Alzheimer's Disease Psychosocial Factors Peptides Cerebrospinal Fluid Female Relaxation Neural Pathways Physiopathology Mental Disorders Aged Brain Mapping Methods Clinical Assessment Tools Aged: 65+ years Male Female ab: Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD)-associated neurodegeneration. However, NPS lack a consistent relationship with AD pathology. It is unknown whether any common neural circuits can link these clinically disparate while mechanistically similar features with AD pathology. Here, we explored the neural circuits of NPS in AD-associated neurodegeneration using multivariate pattern analysis (MVPA) of resting-state functional MRI data. Data from 98 subjects (70 amnestic mild cognitive impairment and 28 AD subjects) were obtained. The top 10 regions differentiating symptom presence across NPS were identified, which were mostly the fronto-limbic regions (medial prefrontal cortex, caudate, etc.). These 10 regions' functional connectivity classified symptomatic subjects across individual NPS at 69.46-81.27%, and predicted multiple NPS (indexed by Neuropsychiatric Symptom Questionnaire-Inventory) and AD pathology (indexed by baseline and change of beta-amyloid/pTau ratio) all above 70%. Our findings suggest a fronto-limbic dominated neural circuit that links multiple NPS and AD pathology. With further examination of the structural and pathological changes within the circuit, the circuit may shed light on linking behavioral disturbances with AD-associated neurodegeneration. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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