Reduced spontaneous low frequency oscillations as measured with functional near-infrared spectroscopy in mild cognitive impairment.
Spontaneous low frequency oscillations (LFO) in functional imaging data have gained increased interest in the study of cognitive decline. Persons diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD) display alterations in their amount of LFO in various brain regions. This is c...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 1; pp. 283 - 293 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135233775&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135233775 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2019 vid: 13 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135233775 135233775 NLM29362991 10.1007/s11682-018-9827-y NLM29362991 135233775 ppf: 283 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Reduced spontaneous low frequency oscillations as measured with functional near-infrared spectroscopy in mild cognitive impairment. aug: au: Zeller, Julia B. M. Katzorke, Andrea Müller, Laura D. Breunig, Judith Haeussinger, Florian B. Deckert, Jürgen Warrings, Bodo Lauer, Martin Polak, Thomas Herrmann, Martin J. affil: Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Margarete-Höppel-Platz 1, 97080, Würzburg, Germany sug: subj: Spectroscopy, Near-Infrared Cerebral Cortex Cerebral Cortex Physiopathology Neuroradiography Relaxation Young Adult Adult Middle Age Periodicity Hemoglobins Metabolism Male Aged Female Clinical Assessment Tools Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Spontaneous low frequency oscillations (LFO) in functional imaging data have gained increased interest in the study of cognitive decline. Persons diagnosed with mild cognitive impairment (MCI) and Alzheimer's disease (AD) display alterations in their amount of LFO in various brain regions. This is commonly interpreted as disruptions in the autoregulation of the cerebral microvascular system. In the present study LFO (0,07-0,11 Hz) were measured with 52-channel near-infrared spectroscopy (NIRS) in 61 healthy elderly persons (70-76 years), 54 MCI subjects (70-76 years) and 25 healthy young controls (21-48 years) during rest over the frontal and the parietal cortex. Both MCI and healthy elderly controls showed less LFO in the frontal cortex as compared to young subjects. For the parietal cortex a decrease in LFO could be observed for the MCI group in comparison to healthy elderly subjects. Correlations of more LFO with worse performance in neuropsychological tests point to compensatory processes. LFO measured with NIRS might be especially suited for longitudinal studies aiming at predicting cognitive decline. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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