Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study.
The APOE ε4 allele is associated with impaired intrinsic functional connectivity in neural networks, especially in the default mode network (DMN). However, effective connectivity (EC) reflects the direct causal effects of one brain region to another, which has rarely been investigated. Recently, Gra...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 1; pp. 270 - 283 |
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| Autores principales: | , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135233782&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135233782 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2019 vid: 13 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135233782 135233782 NLM29549664 10.1007/s11682-018-9857-5 NLM29549664 135233782 ppf: 270 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Altered effective connectivity anchored in the posterior cingulate cortex and the medial prefrontal cortex in cognitively intact elderly APOE ε4 carriers: a preliminary study. aug: au: Luo, Xiao Li, Kaicheng Jia, Y. L. Zeng, Qingze Jiaerken, Yeerfan Qiu, Tiantian Huang, Peiyu Xu, Xiaojun Shen, Zhujing Guan, Xiaojun Zhou, Jiong Wang, Chao Xu, J. J. Zhang, Minming for the Alzheimer's Disease Neuroimaging Initiative (ADNI) affil: Department of Radiology, The 2nd Affiliated Hospital of Zhejiang University School of Medicine, No.88 Jie-Fang Road, 310009, Hangzhou, Shang-Cheng District, China sug: subj: Limbic System Physiopathology Aging Physiology Frontal Lobe Physiopathology Apolipoproteins Aging Aged Heterozygote Brain Mapping Methods Limbic System Magnetic Resonance Imaging Relaxation Neural Pathways Physiopathology Male Neural Pathways Frontal Lobe Cross Sectional Studies Female Clinical Assessment Tools Aged: 65+ years Male Female ab: The APOE ε4 allele is associated with impaired intrinsic functional connectivity in neural networks, especially in the default mode network (DMN). However, effective connectivity (EC) reflects the direct causal effects of one brain region to another, which has rarely been investigated. Recently, Granger causality analysis (GCA) proved suitable for the study of directionality in neuronal interactions. Using GCA, we examined the differences in the EC between the anterior medial prefrontal cortex/posterior cingulate cortex (aMPFC/PCC) and the whole brain in 17 ε4 carrying and 32 non-carrying cognitively intact elderly individuals. Furthermore, correlation analyses were performed between the abnormal EC and cognition/neuropathological indices. Compared with the non-carriers, the results showed that the ε4 carriers exhibited decreased EC from the PCC to the whole brain in the middle temporal gyrus (MTG), the anterior cingulate cortex (ACC), and the precuneus (PCu). Meanwhile, the ε4 carriers demonstrated increased EC from the whole brain to the aMPFC in the inferior parietal lobe (IPL) and the postcentral gyrus (PCG). The correlation analyses suggested that the EC from the IPL/PCG to the aMPFC was related to episodic memory in non-carriers, while the decreased EC from the PCC to the ACC was associated with increased levels of t-tau in the ε4 carriers. In ε4 carriers, a negative influence can be traced from the PCC to both the anterior and posterior DMN subsystems; meanwhile, the anterior DMN subsystem receives compensatory effects from the parietal cortex. Early increases in AD-related pathologies in the PCC may act as first factors during this pathological process. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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