Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson's disease patients.
The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor...
| Publicado en: | Brain Imaging & Behavior Vol. 13; no. 1; pp. 232 - 241 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135233784&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135233784 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19317557 3GSC jtl: Brain Imaging & Behavior issn: 19317557 maglogo: N pubinfo: dt: Feb2019 vid: 13 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135233784 135233784 NLM29629498 10.1007/s11682-018-9863-7 NLM29629498 135233784 ppf: 232 ppct: 9 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Multifocal alterations of white matter accompany the transition from normal cognition to dementia in Parkinson's disease patients. aug: au: Chondrogiorgi, Maria Astrakas, Loukas G. Zikou, Anastasia K. Weis, Luca Xydis, Vassilios G. Antonini, Angelo Argyropoulou, Maria I. Konitsiotis, Spiridon affil: Department of Neurology, Medical School, University of Ioannina, Stavrou Niarchou Av., University Campus, 45110, Ioannina, Greece sug: subj: Cognition Dementia Magnetic Resonance Imaging Methods Parkinson Disease Psychosocial Factors Brain Parkinson Disease Dementia Etiology Disease Progression Male Aged Female Image Interpretation, Computer Assisted Methods Cross Sectional Studies Neuropsychological Tests Scales Aged: 65+ years Male Female ab: The purpose of the present study was to investigate the pattern of white matter (WM) changes associated with Parkinson's disease (PD)-related cognitive impairment by using fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) measures. Diffusion Tensor Imaging (DTI) was performed in 21 PD-patients with dementia (PDD) and in an age-matched control group including 40 PD-patients without dementia (PD-CTRL). The Parkinson's disease-Cognitive Rating Scale (PD-CRS) was used for patients' neuropsychological assessment. Local microstructural WM differences associated with the presence of cognitive impairment were tested using tract-based spatial statistics analysis. Multiple regression models investigated the association of DTI indices with total PD-CRS score, PD-CRS raw items and other clinical measures across the whole study sample. Significant FA decreases were found in PDD compared to PD-CTRL patients mainly in the body of corpus callosum, corona radiata and cingulum. Lower PD-CRS score was significantly associated with decreased FA, MD and AD values in multiple WM tracts primarily located in prefrontal and limbic areas as well as across the corpus callosum. Lower performance in specific PD-CRS raw items was also associated with FA decreases in major WM tracts. The results suggest that multifocal microstructural changes of WM accompany the transition from normal to demented cognitive state in PD-patients. The corpus callosum, the corona radiata and the cingulum are among the regions mostly affected during this course. A progressive axonal degeneration is proposed as a key underlying mechanism. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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