Chlorhexidine-Related Mortality Rate in Critically Ill Subjects in Intensive Care Units: A Systematic Review and Meta-Analysis.
BACKGROUND: This meta-analysis aimed to explore the chlorhexidine-related mortality rate for subjects on mechanical ventilation and in an ICU when compared with subjects who received standard ICU care. METHODS: We searched a number of medical literature databases and the first 100 results in an inte...
| Publicado en: | Respiratory Care Vol. 64; no. 3; pp. 338 - 351 |
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| Autores principales: | , , , , , , |
| Formato: | research systematic review tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135360576&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135360576 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Mar2019 vid: 64 iid: 3 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 135360576 135360576 135360576 10.4187/respcare.06434 135360576 ppf: 338 ppct: 13 formats: fmt: @attributes: type: P tig: atl: Chlorhexidine-Related Mortality Rate in Critically Ill Subjects in Intensive Care Units: A Systematic Review and Meta-Analysis. aug: au: Sojung Lee Lighvan, Nima Laghapour McCredie, Victoria Pechlivanoglou, Petros Krahn, Murray Quiñonez, Carlos Azarpazhooh, Amir affil: Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada sug: subj: Pneumonia, Ventilator-Associated Drug Therapy Chlorhexidine Administration and Dosage Hospital Mortality Critically Ill Patients Intensive Care Units Human Systematic Review Meta Analysis Medline Embase Respiration, Artificial Mantel-Haenszel Test Chi Square Test ab: BACKGROUND: This meta-analysis aimed to explore the chlorhexidine-related mortality rate for subjects on mechanical ventilation and in an ICU when compared with subjects who received standard ICU care. METHODS: We searched a number of medical literature databases and the first 100 results in an internet search. Two of us independently reviewed the titles and abstracts of the identified articles. Then general and specific characteristics from eligible articles were extracted and the quality of included trials were appraised by using a risk of bias assessment tool. Risk ratios were calculated, together with the 95% CI. Random-effects models with the Mantel-Haenszel method were used to estimate pooled probabilities. Heterogeneity was identified and quantified via the chi square test and I² values, respectively. RESULTS: Eleven of the 547 studies were suitable for this meta-analysis. The included participants were critically ill adults in ICU settings of high-income countries (n = 1157) and low/middle-income countries (n= 612). They were assigned to either the chlorhexidine or control groups. Overall, moderate-quality evidence indicated reduced ventilator-associated pneumonia incidence (for high-income countries: RR 0.60, 95% CI 0.41- 0.87; P= .008; I² = 39%; and for low- and middle-income countries: RR 0.71, 95% CI 0.51- 0.99; P=_ .05; I² = 10%), without a substantial effect on mortality rate (for high-income countries: RR 1.01, 95% CI 0.65-1.57; P= .96; I² = 42%; and for low- and middle-income countries: RR 1.11, 95% CI 0.96 -1.29; P = .17; I² = 0%). CONCLUSIONS: The prophylactic administration of chlorhexidine among patients who were critically ill and in an ICU setting reduced the occurrence of ventilator-associated pneumonia with no significant impact on associated mortality. pubtype: Academic Journal doctype: meta analysis research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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