Radiographic stool quantification: an equivalence study of 484 symptomatic and asymptomatic subjects.
Purpose: To determine if symptomatic patients referred for radiographic stool quantification have equivalent stool burden to asymptomatic patients.Method: This was an IRB-approved HIPAA-compliant retrospective equivalence cohort study. An a priori equivalence power calculation was performed. Consecu...
| Publicado en: | Abdominal Radiology Vol. 44; no. 3; pp. 821 - 828 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135395012&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135395012 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Mar2019 vid: 44 iid: 3 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135395012 10.1007/s00261-018-1869-5 135395012 ppf: 821 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Radiographic stool quantification: an equivalence study of 484 symptomatic and asymptomatic subjects. aug: au: Khan, Omar Shankar, Prasad R. Parikh, Adish D. Cohan, Richard H. Keshavarzi, Nahid Khalatbari, Shokoufeh Saad, Richard J. Davenport, Matthew S. affil: Department of Radiology, Michigan Medicine, 1500 E. Medical Center Drive, 48109, Ann Arbor, MI, USA sug: ab: Purpose: To determine if symptomatic patients referred for radiographic stool quantification have equivalent stool burden to asymptomatic patients.Method: This was an IRB-approved HIPAA-compliant retrospective equivalence cohort study. An a priori equivalence power calculation was performed. Consecutive abdominal radiographs performed in adult outpatients with bloating, constipation, diarrhea, or abdominal pain to assess "fecal loading" [n = 242 (fecal cohort)] were compared to those performed in asymptomatic adult outpatients to assess "renal stones" [n = 242 (renal cohort)]. Radiographs were randomized and reviewed by two blinded independent abdominal radiologists. Exclusion criteria, designed to avoid unblinding, included urinary tract calculi ≥ 0.5 cm, multiple urinary tract calculi, and ureteral stent(s). Readers scored all radiographs (n = 484) for stool burden using validated Leech criteria [scale: 0 (none) to 15 (extreme diffuse)]. Mean Leech scores and 95% confidence intervals were calculated. Multivariable generalized linear modeling was performed to adjust for baseline medication use, age, and gender. The adjusted parameter estimate was used to test for equivalence in the mean difference between cohorts using Schuirmann's method of two one-sided t-tests. Inter-reader agreement was assessed with intraclass correlation coefficients.Results: Overall mean Leech scores for fecal [6.9 (95% CI 6.7, 7.2)] and renal [7.3 (95% CI 7.1, 7.5)] cohorts were equivalent within a margin of 0.75 (adjusted mean difference: − 0.4 [90% CI − 0.7, − 0.04]; p value = 0.02). Inter-reader agreement was good [ICC: 0.62 (95% CI 0.56, 0.68)].Conclusion: Radiographic stool quantification produces equivalent results in symptomatic and asymptomatic adults and is of uncertain value. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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