Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide.
Background: Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, but its inhibition of sucrose intake is not affected. This is suggestive of sepa...
| Publicado en: | BMC Neuroscience Vol. 20; no. 1 |
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| Autores principales: | , , |
| Formato: | research Journal Article |
| Publicado: |
BioMed Central
3/18/2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135400396&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135400396 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14712202 1CI8 jtl: BMC Neuroscience issn: 14712202 maglogo: N pubinfo: dt: 3/18/2019 vid: 20 iid: 1 pid: 24147 pub: BioMed Central artinfo: ui: 135400396 135400396 NLM30885137 135400396 10.1186/s12868-019-0494-8 NLM30885137 135400396 ppct: 1 formats: tig: atl: Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide. aug: au: Smedh, Ulrika Scott, Karen A. Moran, Timothy H. affil: The Surgical Metabolic Research Laboratory, Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg, and Sahlgrenska University Hospital, 413 45, Gothenburg, Sweden sug: subj: Nerve Tissue Proteins Pharmacodynamics Brain Stem Drug Effects Peptides Pharmacodynamics Corticotropin-Releasing Hormone Antagonists and Inhibitors Eating Drug Effects Central Nervous System Agents Pharmacodynamics Peptides Metabolism Eating Physiology Animal Studies Corticotropin-Releasing Hormone Metabolism Rats Brain Stem Metabolism Male Injections, Intraventricular Nerve Tissue Proteins Metabolism Corticotropin-Releasing Hormone Pharmacodynamics Cerebral Ventricles Validation Studies Comparative Studies Evaluation Research Multicenter Studies Male ab: Background: Pre-treatment with the corticotropin-releasing factor antagonist α-helical CRF9-41 prevents inhibition of gastric emptying by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level, but its inhibition of sucrose intake is not affected. This is suggestive of separable underlying mechanisms of action in the caudal brainstem for cocaine-and amphetamine-regulated transcript peptide with regard to food intake and gastrointestinal functions. Here we further examine cocaine-and amphetamine-regulated transcript peptide-corticotropin-releasing factor receptor interactions in caudal brainstem controls of solid food intake. Injections of combinations of vehicle, cocaine-and amphetamine-regulated transcript peptide (0.5 μg or 1 μg) or α-helical CRF9-41 were given into the fourth cerebral ventricle of rats. Nocturnal solid food intake was recorded over 22 h.Results: Pre-treatment with α-helical CRF9-41 into the fourth ventricle significantly increased the responsivity to cocaine-and amphetamine-regulated transcript peptide on hypophagia. In a separate control experiment, α-helical CRF9-41 pre-treatment blocked CRF-induced food intake inhibition indicative of its antagonistic effectiveness.Conclusions: We conclude that an endogenous Corticotropin-releasing factor agonist may modulate suppression of food intake caused by cocaine-and amphetamine-regulated transcript peptide at a dorsal hindbrain level in the absence of stress. A potential caudal brainstem mechanism whereby cocaine-and amphetamine-regulated transcript peptide effects on food intake is attenuated via corticotropin-releasing factor receptor activity causing tonic inhibition, is suggested. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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