Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults.
Purpose: To investigate the cross-sectional and prospective associations between patterns of serum fat-soluble micronutrients and frailty in four European cohorts of older adults 65 years of age and older.Methods: Participants from the Three-City (Bordeaux, France), AMI (Gironde, France), TSHA (Tole...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 1; pp. 379 - 390 |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135451148&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135451148 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2019 vid: 58 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135451148 135451148 135451148 10.1007/s00394-017-1602-0 135451148 ppf: 379 ppct: 11 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Patterns of circulating fat-soluble vitamins and carotenoids and risk of frailty in four European cohorts of older adults. aug: au: Pilleron, Sophie Weber, Daniela Pérès, Karine Colpo, Marco Gomez-Cabrero, David Stuetz, Wolfgang Dartigues, Jean-François Ferrucci, Luigi Bandinelli, Stefania Garcia-Garcia, Francisco Jose Grune, Tilman Féart, Catherine On behalf of the FRAILOMIC initiative affil: Inserm, Bordeaux Population Health Research Center, UMR 1219, University Bordeaux, 33000, Bordeaux, France sug: subj: Vitamins Blood Carotenoids Blood Frailty Syndrome In Old Age Risk Assessment Human Europe Solubility Aged Aged, 80 and Over France Spain Italy beta Carotene Blood Lycopene Blood Lutein Blood Zeaxanthin Blood Vitamin A Blood Factor Analysis Cholecalciferol Blood Multivariate Analysis Logistic Regression Serum Odds Ratio Confidence Intervals Descriptive Statistics Aged: 65+ years Aged, 80 & over ab: Purpose: To investigate the cross-sectional and prospective associations between patterns of serum fat-soluble micronutrients and frailty in four European cohorts of older adults 65 years of age and older.Methods: Participants from the Three-City (Bordeaux, France), AMI (Gironde, France), TSHA (Toledo, Spain) and InCHIANTI (Tuscany, Italy) cohorts with available data on serum α-carotene, β-carotene, lycopene, cryptoxanthin, lutein + zeaxanthin, retinol, α-tocopherol, γ-tocopherol and 25-hydroxyvitamin D3 (25(OH)D) were included. A principal component (PC) analysis was used to derive micronutrient patterns. Frailty was defined using Fried's criteria. Multivariate logistic regression models adjusted for socio-demographic and health-related covariates were performed to assess the association between micronutrient patterns and prevalent frailty in 1324 participants, and the risk of frailty in 915 initially non-frail participants.Results: Three different patterns were identified: the first pattern was characterized by higher serum carotenoids and α-tocopherol levels; the second was characterized by high loadings for serum vitamins A and E levels and low loadings for carotenes level; the third one had the highest loading for serum 25(OH)D and cryptoxanthin level and the lowest loading for vitamin A and E. A significant cross-sectional association was only observed between the seconnd PC and prevalent frailty (p = 0.02). Compared to the highest quartile, participants in the lowest quartile—i.e., high carotenes and low vitamins E and A levels—had higher odds of frailty (Odds ratio = 2.2; 95% confidence interval 1.3-3.8). No association with the risk of frailty was observed.Conclusions: These findings suggest that some specific micronutrient patterns are markers but not predictors of frailty in these European cohorts of older adults. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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