Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood.
Background: Clinicians often use information about developmental outcomes in decision-making around offering complex, life-saving interventions in children such as dialysis and renal transplant. This information in children with end-stage renal disease (ESRD) is limited, particularly when ESRD onset...
| Published in: | Pediatric Nephrology Vol. 34; no. 5; pp. 889 - 896 |
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| Main Authors: | , , , , , , , , |
| Format: | research Journal Article |
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Springer Nature
May2019
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135451186&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135451186 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: May2019 vid: 34 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135451186 135451186 135451186 10.1007/s00467-018-4158-1 135451186 ppf: 889 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Neurocognitive and functional outcomes at 5 years of age after renal transplant in early childhood. aug: au: Popel, Jillian Joffe, Rachel Acton, Bryan V. Bond, Gwen Y. Joffe, Ari R. Midgley, Julian Robertson, Charlene M. T. Sauve, Reg S. Morgan, Catherine J. affil: Department of Pediatrics, Edmonton Clinic Health Academy, University of Alberta, 11405 - 87 Ave, T6G 1C9, Edmonton, AB, Canada sug: subj: Kidney Transplantation In Infancy and Childhood Kidney Failure, Chronic Surgery Cognition Functional Status In Infancy and Childhood Human Child, Preschool Infant Age of Onset Prospective Studies Treatment Outcomes Functional Assessment In Infancy and Childhood Cognition Disorders Child Development Developmental Disabilities Child, Preschool: 2-5 years Infant: 1-23 months ab: Background: Clinicians often use information about developmental outcomes in decision-making around offering complex, life-saving interventions in children such as dialysis and renal transplant. This information in children with end-stage renal disease (ESRD) is limited, particularly when ESRD onset is in infancy or early childhood.Methods: Using data from an ongoing prospective, longitudinal, inception cohort study of children with renal transplant before 5 years of age, we evaluated (1) the risk of adverse neurocognitive and functional outcomes at 5 years of age and (2) predictors of developmental outcomes.Results: We found evidence of neurocognitive sequelae of ESRD in very young children; however, developmental outcomes appear remarkably better when compared with findings of two or three decades ago. Less time on dialysis predicted higher developmental scores, and hemodialysis was associated with poorer developmental outcomes.Conclusions: Our data suggest that renal replacement therapies in young children are associated with acceptable developmental outcome. Programs to identify those with developmental delays and provide early intervention may allow achievement of the child's full potential. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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