Differential Potentiation of Retinoic Acid Effects against Human Breast Cancer Cells by Unsaturated Fatty Acids.
Retinoic acid (RA) and unsaturated fatty acids (UFA) are proposed as nutritional anticancer agents. Nonetheless, the activity of their combination on human breast cancer needs further study. Our aim was to evaluate this activity on the MCF-7 and ZR-75-1 cell lines treated with 1 µM RA and 50 µM of γ...
| Publicado en: | Nutrition & Cancer Vol. 70; no. 7; pp. 1137 - 1145 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Oct2018
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135476388&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135476388 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01635581 7MS jtl: Nutrition & Cancer issn: 01635581 maglogo: N pubinfo: dt: Oct2018 vid: 70 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 135476388 135476388 135476388 10.1080/01635581.2018.1497669 135476388 ppf: 1137 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Differential Potentiation of Retinoic Acid Effects against Human Breast Cancer Cells by Unsaturated Fatty Acids. aug: au: Quiroga, Patricia L. Soria, Elio A. Valentich, Mirta A. Eynard, Aldo R. affil: Cátedra de Biología Celular, Histología y Embriología, Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina sug: subj: Breast Neoplasms Drug Therapy Fatty Acids, Unsaturated Pharmacodynamics Tretinoin Pharmacodynamics Tretinoin Administration and Dosage Fatty Acids, Unsaturated Administration and Dosage Cell Line, Tumor Drug Effects Drug Synergism Human Eicosapentaenoic Acid Pharmacodynamics Eicosanoids Pharmacodynamics Linoleic Acids Pharmacodynamics Analysis of Variance Fisher's Exact Test Regression Cell Differentiation Drug Effects Cell Viability Drug Effects gamma-Glutamyltransferase Drug Effects Cell Adhesion Molecules Drug Effects Microfilament Proteins Drug Effects ab: Retinoic acid (RA) and unsaturated fatty acids (UFA) are proposed as nutritional anticancer agents. Nonetheless, the activity of their combination on human breast cancer needs further study. Our aim was to evaluate this activity on the MCF-7 and ZR-75-1 cell lines treated with 1 µM RA and 50 µM of γ-linoleic (GLA, ω-6), eicosapentaenoic (EPA, ω-3), oleic (OA, ω-9), or eicosatrienoic (ETA, ω-9) acids. The following cellular responses were compared by ANOVA and Fisher test (P < 0.05): fatty acids, E-cadherin, actin (differentiation), conjugated dienes, γ-glutamyltranspeptidase activity (stress), and viability, which were correlated by partial least squares regression. Although both cell lines responded differentially, RA modified unsaturated fatty acids, increased differentiation, reduced γ-glutamyltranspeptidase, and viability. RA differentiating activity on ZR-75-1 was morphologically enhanced by UFA. Stress induction with γ-glutamyltranspeptidase decrease and conjugated dienes was promoted by ETA in MCF-7, and EPA and OA in ZR-75-1. RA-related reduced viability was potentiated by EPA and OA in both lines. GLA was less active. Therefore, unsaturated fatty acids (ω-3/ω-9) potentiated the multitarget retinoic acid activity against these human breast cancer cells. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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