Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial.
Purpose: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed t...
| Publicado en: | European Journal of Nutrition Vol. 58; no. 2; pp. 673 - 681 |
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| Autores principales: | , , , , , , , , , , , |
| Formato: | research tables/charts randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Mar2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135579580&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135579580 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Mar2019 vid: 58 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135579580 135579580 135579580 10.1007/s00394-018-1666-5 135579580 ppf: 673 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial. aug: au: Zittermann, Armin Ernst, Jana B. Prokop, Sylvana Fuchs, Uwe Dreier, Jens Kuhn, Joachim Knabbe, Cornelius Berthold, Heiner K. Gouni-Berthold, Ioanna Gummert, Jan F. Börgermann, Jochen Pilz, Stefan affil: Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Georgstraße 11, 32545, Bad Oeynhausen, Germany sug: subj: Vitamin D Therapeutic Use Dietary Supplementation Testosterone Heart Failure Human Male Nonexperimental Studies Randomized Controlled Trials Random Assignment Treatment Outcomes Confidence Intervals Sex Hormones Cholecalciferol Administration and Dosage Glycoproteins Male ab: Purpose: Observational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients. Methods: In a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations < 75 nmol/L the effect of a daily vitamin D3 supplement of 4000 IU for 3 years (n = 71) vs. placebo (n = 62) on total T (TT), sex hormone-binding globulin (SHBG), free T (fT), and bioactive T (BAT). We assessed changes from baseline until study termination and between-group differences at study termination. Results: 25OHD increased in the placebo group from 36.6 nmol/L by 9.2 nmol/L (95% CI 3.2–15.1 nmol/L; P = 0.003) and in the vitamin D group from 36.5 nmol/L by 63.9 nmol/L (95% CI 52.6–75.3 nmol/L; P < 0.001), with a significant between-group difference at study termination (P < 0.001). TT and SHBG concentrations did not change significantly, neither in the placebo group nor in the vitamin D group (P = 0.845–0.082), but concentrations of fT and BAT declined significantly in both groups (P = 0.025–0.008). At study termination, there were no between-group differences in TT (P = 0.612), SHBG (P = 0.393), fT (P = 0.861), or BAT (P = 0.960). Conclusions: In male patients with advanced HF and low 25OHD concentrations, a daily vitamin D3 supplement of 4000 IU for 3 years did not prevent the decline in testosterone indices. pubtype: Academic Journal doctype: research tables/charts randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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