Accuracy of invasive and noninvasive methods of Helicobacter pylori infection diagnosis in Saudi children.
Background/Aim: Helicobacter pylori (H. pylori) infection is one of the most common chronic infections in the world. The prevalence of H. pylori is high in Saudi Arabia, but there are no studies in children on the accuracy of invasive and noninvasive methods to diagnose H. pylori infection. The aim...
| Publicado en: | Saudi Journal of Gastroenterology Vol. 25; no. 2; pp. 126 - 132 |
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| Autor principal: | |
| Formato: | research tables/charts Journal Article |
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Wolters Kluwer India Pvt Ltd
Mar/Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135627077&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135627077 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13193767 322P jtl: Saudi Journal of Gastroenterology issn: 13193767 maglogo: N pubinfo: dt: Mar/Apr2019 vid: 25 iid: 2 pid: 16919 pub: Wolters Kluwer India Pvt Ltd artinfo: ui: 135627077 135627077 135627077 10.4103/sjg.SJG_288_18 135627077 ppf: 126 ppct: 6 formats: tig: atl: Accuracy of invasive and noninvasive methods of Helicobacter pylori infection diagnosis in Saudi children. aug: au: Hasosah, Mohammed affil: Department of Pediatric Gastroenterology, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Jeddah sug: subj: Invasive Procedures Methods Noninvasive Procedures Methods Helicobacter Infections Diagnosis Pediatric Care Sensitivity and Specificity Human Validity Prospective Studies Cross Sectional Studies Saudi Arabia Hospitals, Pediatric Endoscopy, Digestive System Tissue Culture Techniques Prevalence Helicobacter Infections Epidemiology Confidence Intervals Child Urease Analysis Histological Techniques Methods Biopsy Methods Serologic Tests Antigens, Bacterial Analysis Feces Analysis Child: 6-12 years ab: Background/Aim: Helicobacter pylori (H. pylori) infection is one of the most common chronic infections in the world. The prevalence of H. pylori is high in Saudi Arabia, but there are no studies in children on the accuracy of invasive and noninvasive methods to diagnose H. pylori infection. The aim of this study was to evaluate the accuracy of six methods for diagnosis of H. pylori infection; four invasive [rapid urease test (RUT), histology, antral nodularity (AD), and biopsy culture (BC)] and two noninvasive methods [serologic test and stool antigen test (SAT)]. Patients and Methods: A prospective cross-sectional study was performed among symptomatic children in National Guard hospitals who underwent esophagogastroduodenoscopy from 2010 to 2013. The gold standard diagnosis of H. pylori was positive tissue culture. If the culture was unsuccessful or not done, concordant-positive results for histology and RUT were considered to indicate a positive H. pylori. The variables analyzed as diagnostic methods included RUT, BC, histology, AD, serologic test, and SAT. Results: A total of 303 children were included in the study. The overall prevalence of H. pylori infection was 49.8%. Most diagnostic tests showed high specificity and moderate-to-low sensitivity when compared to the gold standard test. Sensitivity of AD, SAT, and RUT to detect H. pylori were 62% (95% CI: 0.51–0.74), 69% (95% CI: 0.58–0.79), and 87% (95% CI: 0.79–0.95), respectively (P value 0.040, 0.0023, and <0.0001, respectively). RUT showed the lowest specificity, 65% (95% CI: 0.58–0.71) in contrast to BC and histology which showed moderate-to-high specificities of 88% (95% CI: 0.82–0.95) and 89% (95% CI: 0.82–0.95), respectively (P <0.0001). Conclusion: RUT is a valuable diagnostic method for identifying H. pylori with the highest sensitivity compared to AD and SAT. All diagnostic tests showed moderate-to-high specificities but BC and histology showed the highest specificity. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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