Liver fibrosis assessment using 99mTc-GSA SPECT/CT fusion imaging.
Purpose: To determine the utility of mean standardized uptake value (SUVmean) of whole liver measured by 99mTc-GSA SPECT/CT fusion imaging, for evaluation of liver fibrosis.Materials and Methods: Eighty-six patients who underwent hepatectomy were enrolled, and were classified into the non-fibrosis o...
| Publicado en: | Japanese Journal of Radiology Vol. 37; no. 4; pp. 315 - 321 |
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| Autores principales: | , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Apr2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135662133&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135662133 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 18671071 AUCM jtl: Japanese Journal of Radiology issn: 18671071 maglogo: N pubinfo: dt: Apr2019 vid: 37 iid: 4 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135662133 135662133 NLM30656542 10.1007/s11604-019-00810-w NLM30656542 135662133 ppf: 315 ppct: 6 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Liver fibrosis assessment using 99mTc-GSA SPECT/CT fusion imaging. aug: au: Tokorodani, Ryotaro Sumiyoshi, Tatsuaki Okabayashi, Takehiro Hata, Yasuhiro Noda, Yoshihiro Morita, Sojiro Daisaki, Hiromitsu Okada, Yukinori Yasuda, Eisuke affil: Department of Radiological Technology, Kochi Health Sciences Center, Kochi, Japan sug: subj: Albumins Liver Cirrhosis Radiopharmaceuticals Liver Cirrhosis Surgery Female Hepatectomy Middle Age Liver Surgery Reproducibility of Results Liver Pathology Liver Cirrhosis Pathology Male Aged, 80 and Over Aged Sensitivity and Specificity Retrospective Design Liver Liver Function Tests Adult ROC Curve Middle Aged: 45-64 years Aged, 80 & over Aged: 65+ years Adult: 19-44 years Female Male ab: Purpose: To determine the utility of mean standardized uptake value (SUVmean) of whole liver measured by 99mTc-GSA SPECT/CT fusion imaging, for evaluation of liver fibrosis.Materials and Methods: Eighty-six patients who underwent hepatectomy were enrolled, and were classified into the non-fibrosis or fibrosis group based on the pathological findings in the resected liver specimen. Univariate and multivariate analyses were performed between the two groups on four blood biochemical indices (albumin, total bilirubin, platelet count, and prothrombin time activity) and two 99mTc-GSA scintigraphy-derived liver function indices (LHL15 and SUVmean) to evaluate the independent predictive value for severe fibrosis. The diagnostic value of the index for severe fibrosis was assessed by calculating the area under the receiver operating characteristic curve.Results: Multivariate analysis showed that prothrombin time activity [odds ratio (OR) 0.519], LHL15 (OR 0.513), and SUVmean (OR 0.168) significantly correlated with liver fibrosis. SUVmean showed the largest area under the curve, with value of 0.804, 0.730 for platelet count, 0.717 for LHL15, and 0.668 for prothrombin time activity. The optimal cut-off value for SUVmean was 6.7, which yielded 62.9% sensitivity and 96.9% specificity.Conclusions: SUVmean measured by 99mTc-GSA SPECT/CT fusion imaging enables highly accurate prediction of severe liver fibrosis. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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