Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence.
Objective: To validate a radial imaging spin-echo diffusion tensor (RAISED) sequence for high-resolution diffusion tensor imaging (DTI) of articular cartilage at 3 T.Methods: The RAISED sequence implementation is described, including the used non-linear motion correction algorithm. The robustness to...
| Publicado en: | European Radiology Vol. 29; no. 5; pp. 2598 - 2608 |
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| Autores principales: | , , , , , , , |
| Formato: | diagnostic images pictorial research tables/charts Journal Article |
| Publicado: |
Springer Nature
May2019
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=135662811&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 135662811 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: May2019 vid: 29 iid: 5 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 135662811 135662811 NLM30382348 135662811 10.1007/s00330-018-5780-9 NLM30382348 135662811 ppf: 2598 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence. aug: au: Duarte, Alejandra Ruiz, Amparo Ferizi, Uran Bencardino, Jenny Abramson, Steven B. Samuels, Jonathan Krasnokutsky-Samuels, Svetlana Raya, José G. affil: Center for Biomedical Imaging, Department of Radiology, New York University Langone Health, 660 First avenue, 4th Floor, 10016, New York, NY, USA sug: subj: Magnetic Resonance Imaging Methods Knee Joint Phantoms, Imaging Osteoarthritis, Knee Diagnosis Cartilage, Articular Pathology Algorithms Reproducibility of Results Male Adult Epiphyses Pathology Middle Age Female Human Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Objective: To validate a radial imaging spin-echo diffusion tensor (RAISED) sequence for high-resolution diffusion tensor imaging (DTI) of articular cartilage at 3 T.Methods: The RAISED sequence implementation is described, including the used non-linear motion correction algorithm. The robustness to eddy currents was tested on phantoms, and accuracy of measurement was assessed with measurements of temperature-dependent diffusion of free water. Motion correction was validated by comparing RAISED with single-shot diffusion-weighted echo-planar imaging (EPI) measures. DTI was acquired in asymptomatic subjects (n = 6) and subjects with doubtful (Kellgren-Lawrence [KL] grade 1, n = 9) and mild (KL = 2, n = 9) symptomatic knee osteoarthritis (OA). MD and FA values without correction, and after all corrections, were calculated. A test-retest evaluation of the DTI acquisition on three asymptomatic and three OA subjects was also performed.Results: The root mean squared coefficient of variation of the global test-restest reproducibility was 3.54% for MD and 5.34% for FA. MD was significantly increased in both femoral condyles (7-9%) of KL 1 and in the medial (11-17%) and lateral (10-12%) compartments of KL 2 subjects. Averaged FA presented a trend of lower values with increasing KL grade, which was significant for the medial femoral condyle (-11%) of KL 1 and all three compartments in KL 2 subjects (-18 to -11%). Group differences in MD and FA were only significant after motion correction.Conclusion: The RAISED sequence with the proposed reconstruction framework provides reproducible assessment of DTI parameters in vivo at 3 T and potentially the early stages of the disease in large regions of interest.Key Points: • DTI of articular cartilage is feasible at 3T with a multi-shot RAISED sequence with non-linear motion correction. • RAISED sequence allows estimation of the diffusion indices MD and FA with test-retest errors below 4% (MD) and 6% (FA). • RAISED-based measurement of DTI of articular cartilage with non-linear motion correction holds potential to differentiate healthy from OA subjects. pubtype: Academic Journal doctype: diagnostic images pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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